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TargetE2 ubiquitin-conjugating enzyme E1
LigandBDBM329889
Substrate/Competitorn/a
Meas. Tech.HTRF Assay
IC50<10±n/a nM
Citation Afroze RBharathan ITCiavarri JPFleming PEGaulin JLGirard MLangston SPSoucy FWong TYe Y Pyrazolopyrimidinyl inhibitors of ubiquitin-activating enzyme US Patent  US9663525 Publication Date 5/30/2017
More Info.:Get all data from this article,  Assay Method
 
E2 ubiquitin-conjugating enzyme E1
Name:E2 ubiquitin-conjugating enzyme E1
Synonyms:n/a
Type:n/a
Mol. Mass.:21408.98
Organism:Homo sapiens (Human)
Description:P51965
Residue:193
Sequence:
MSDDDSRASTSSSSSSSSNQQTEKETNTPKKKESKVSMSKNSKLLSTSAKRIQKELADIT
LDPPPNCSAGPKGDNIYEWRSTILGPPGSVYEGGVFFLDITFTPEYPFKPPKVTFRTRIY
HCNINSQGVICLDILKDNWSPALTISKVLLSICSLLTDCNPADPLVGSIATQYMTNRAEH
DRMARQWTKRYAT
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  Blast E-value cutoff:
BDBM329889
n/a
NameBDBM329889
Synonyms:(rac)-((1R,2R,3S,4R)-4-(2-(5-fluoronaphthalen-1-yl)pyrazolo[1,5-a]pyrimidin-7- | US10202389, Compound I-105 | US9663525, Compound I-097 | US9663525, Compound I-105 | US9796725, Compound I-097
TypeSmall organic molecule
Emp. Form.C22H22FN5O5S
Mol. Mass.487.504
SMILESNS(=O)(=O)OC[C@H]1C[C@@H](Nc2ccnc3cc(nn23)-c2cccc3c(F)cccc23)[C@H](O)[C@@H]1O |r|
Structure
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