Ki Summary new BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetE2 ubiquitin-conjugating enzyme E1
LigandBDBM329891
Substrate/Competitorn/a
Meas. Tech.HTRF Assay
IC50<10±n/a nM
Citation Afroze RBharathan ITCiavarri JPFleming PEGaulin JLGirard MLangston SPSoucy FWong TYe Y Pyrazolopyrimidinyl inhibitors of ubiquitin-activating enzyme US Patent  US9663525 Publication Date 5/30/2017
More Info.:Get all data from this article,  Assay Method
 
E2 ubiquitin-conjugating enzyme E1
Name:E2 ubiquitin-conjugating enzyme E1
Synonyms:n/a
Type:n/a
Mol. Mass.:21408.98
Organism:Homo sapiens (Human)
Description:P51965
Residue:193
Sequence:
MSDDDSRASTSSSSSSSSNQQTEKETNTPKKKESKVSMSKNSKLLSTSAKRIQKELADIT
LDPPPNCSAGPKGDNIYEWRSTILGPPGSVYEGGVFFLDITFTPEYPFKPPKVTFRTRIY
HCNINSQGVICLDILKDNWSPALTISKVLLSICSLLTDCNPADPLVGSIATQYMTNRAEH
DRMARQWTKRYAT
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM329891
n/a
NameBDBM329891
Synonyms:(rac)-rel-5-[7-({(1R,2S,3R,4R)-2,3-dihydroxy-4- | US10202389, Compound I-099 | US9663525, Compound I-099
TypeSmall organic molecule
Emp. Form.C23H23N5O7S
Mol. Mass.513.523
SMILESNS(=O)(=O)OC[C@H]1C[C@@H](Nc2ccnc3cc(nn23)-c2cccc3cc(ccc23)C(O)=O)[C@H](O)[C@@H]1O |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: