| Reaction Details |
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 | Report a problem with these data |
| Target | Ubiquitin-conjugating enzyme E2 E1 |
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| Ligand | BDBM329900 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | HTRF Assay |
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| IC50 | <10±n/a nM |
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| Citation |  Afroze, R; Bharathan, IT; Ciavarri, JP; Fleming, PE; Gaulin, JL; Girard, M; Langston, SP; Soucy, F; Wong, T; Ye, Y Pyrazolopyrimidinyl inhibitors of ubiquitin-activating enzyme US Patent US9663525 Publication Date 5/30/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Ubiquitin-conjugating enzyme E2 E1 |
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| Name: | Ubiquitin-conjugating enzyme E2 E1 |
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| Synonyms: | E2 ubiquitin-conjugating enzyme E1 | UB2E1_HUMAN | UBCH6 | UBE2E1 |
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| Type: | n/a |
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| Mol. Mass.: | 21408.98 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P51965 |
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| Residue: | 193 |
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| Sequence: | MSDDDSRASTSSSSSSSSNQQTEKETNTPKKKESKVSMSKNSKLLSTSAKRIQKELADIT
LDPPPNCSAGPKGDNIYEWRSTILGPPGSVYEGGVFFLDITFTPEYPFKPPKVTFRTRIY
HCNINSQGVICLDILKDNWSPALTISKVLLSICSLLTDCNPADPLVGSIATQYMTNRAEH
DRMARQWTKRYAT
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| BDBM329900 |
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| n/a |
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| Name | BDBM329900 |
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| Synonyms: | (s.e.)-[(1R,2R,3S,4R)-4-{[2-(4-chloro-1-naphthyl)pyrazolo[1,5-a]pyrimidin-7- | US10202389, Compound I-108 | US9663525, Compound I-108 | US9796725, Compound I-108 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H22ClN5O5S |
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| Mol. Mass. | 503.959 |
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| SMILES | NS(=O)(=O)OC[C@H]1C[C@@H](Nc2ccnc3cc(nn23)-c2ccc(Cl)c3ccccc23)[C@H](O)[C@@H]1O |r| |
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| Structure | 
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