| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Falcipain-2 |
|---|
| Ligand | BDBM12037 |
|---|
| Substrate/Competitor | BDBM12033 |
|---|
| Meas. Tech. | Falcipain Enzyme Inhibition Assay |
|---|
| pH | 5.5±n/a |
|---|
| Temperature | 295.15±n/a K |
|---|
| IC50 | 1800±n/a nM |
|---|
| Citation |  Dominguez, JN; Leon, C; Rodrigues, J; Gamboa de Dominguez, N; Gut, J; Rosenthal, PJ Synthesis and evaluation of new antimalarial phenylurenyl chalcone derivatives. J Med Chem48:3654-8 (2005) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
|---|
| |
| Falcipain-2 |
|---|
| Name: | Falcipain-2 |
|---|
| Synonyms: | n/a |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 55912.57 |
|---|
| Organism: | Plasmodium falciparum |
|---|
| Description: | n/a |
|---|
| Residue: | 484 |
|---|
| Sequence: | MDYNMDYAPHEVISQQGERFVDKYVDRKILKNKKSLLVIISLSVLSVVGFVLFYFTPNSR
KSDLFKNSSVENNNDDYIINSLLKSPNGKKFIVSKIDEALSFYDSKKNDINKYNEGNNNN
NADFKGLSLFKENTPSNNFIHNKDYFINFFDNKFLMNNAEHINQFYMFIKTNNKQYNSPN
EMKERFQVFLQNAHKVNMHNNNKNSLYKKELNRFADLTYHEFKNKYLSLRSSKPLKNSKY
LLDQMNYEEVIKKYRGEENFDHAAYDWRLHSGVTPVKDQKNCGSCWAFSSIGSVESQYAI
RKNKLITLSEQELVDCSFKNYGCNGGLINNAFEDMIELGGICPDGDYPYVSDAPNLCNID
RCTEKYGIKNYLSVPDNKLKEALRFLGPISISVAVSDDFAFYKEGIFDGECGDELNHAVM
LVGFGMKEIVNPLTKKGEKHYYYIIKNSWGQQWGERGFINIETDESGLMRKCGLGTDAFI
PLIE
|
|
|
|---|
| BDBM12037 |
|---|
| BDBM12033 |
|---|
| Name | BDBM12037 |
|---|
| Synonyms: | 3-(4-chlorophenyl)-1-{4-[(2E)-3-(3,4,5-trimethoxyphenyl)prop-2-enoyl]phenyl}urea | Phenylurenyl Chalcone deriv. 27 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C25H23ClN2O5 |
|---|
| Mol. Mass. | 466.914 |
|---|
| SMILES | COc1cc(\C=C\C(=O)c2ccc(NC(=O)Nc3ccc(Cl)cc3)cc2)cc(OC)c1OC |
|---|
| Structure | 
|
|---|
Search and Browse
