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TargetFalcipain-2
LigandBDBM12037
Substrate/CompetitorBDBM12033
Meas. Tech.Falcipain Enzyme Inhibition Assay
pH5.5±n/a
Temperature295.15±n/a K
IC50 1800±n/a nM
Citation Dominguez JNLeon CRodrigues JGamboa de Dominguez NGut JRosenthal PJ Synthesis and evaluation of new antimalarial phenylurenyl chalcone derivatives. J Med Chem 48:3654-8 (2005) [PubMed]  Article
More Info.:Get all data from this article,  Inhibition_Run data,   Solution Info,  Assay Method
 
Falcipain-2
Name:Falcipain-2
Synonyms:n/a
Type:Enzyme
Mol. Mass.:55912.57
Organism:Plasmodium falciparum
Description:n/a
Residue:484
Sequence:
MDYNMDYAPHEVISQQGERFVDKYVDRKILKNKKSLLVIISLSVLSVVGFVLFYFTPNSR
KSDLFKNSSVENNNDDYIINSLLKSPNGKKFIVSKIDEALSFYDSKKNDINKYNEGNNNN
NADFKGLSLFKENTPSNNFIHNKDYFINFFDNKFLMNNAEHINQFYMFIKTNNKQYNSPN
EMKERFQVFLQNAHKVNMHNNNKNSLYKKELNRFADLTYHEFKNKYLSLRSSKPLKNSKY
LLDQMNYEEVIKKYRGEENFDHAAYDWRLHSGVTPVKDQKNCGSCWAFSSIGSVESQYAI
RKNKLITLSEQELVDCSFKNYGCNGGLINNAFEDMIELGGICPDGDYPYVSDAPNLCNID
RCTEKYGIKNYLSVPDNKLKEALRFLGPISISVAVSDDFAFYKEGIFDGECGDELNHAVM
LVGFGMKEIVNPLTKKGEKHYYYIIKNSWGQQWGERGFINIETDESGLMRKCGLGTDAFI
PLIE
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  Blast E-value cutoff:
BDBM12037
BDBM12033
NameBDBM12037
Synonyms:3-(4-chlorophenyl)-1-{4-[(2E)-3-(3,4,5-trimethoxyphenyl)prop-2-enoyl]phenyl}urea | Phenylurenyl Chalcone deriv. 27
TypeSmall organic molecule
Emp. Form.C25H23ClN2O5
Mol. Mass.466.914
SMILESCOc1cc(\C=C\C(=O)c2ccc(NC(=O)Nc3ccc(Cl)cc3)cc2)cc(OC)c1OC
Structure
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