| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Falcipain-2 |
|---|
| Ligand | BDBM12041 |
|---|
| Substrate/Competitor | BDBM12033 |
|---|
| Meas. Tech. | Falcipain Enzyme Inhibition Assay |
|---|
| pH | 5.5±n/a |
|---|
| Temperature | 295.15±n/a K |
|---|
| IC50 | 5.8±n/a nM |
|---|
| Citation |  Dominguez, JN; Leon, C; Rodrigues, J; Gamboa de Dominguez, N; Gut, J; Rosenthal, PJ Synthesis and evaluation of new antimalarial phenylurenyl chalcone derivatives. J Med Chem48:3654-8 (2005) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
|---|
| |
| Falcipain-2 |
|---|
| Name: | Falcipain-2 |
|---|
| Synonyms: | n/a |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 55912.57 |
|---|
| Organism: | Plasmodium falciparum |
|---|
| Description: | n/a |
|---|
| Residue: | 484 |
|---|
| Sequence: | MDYNMDYAPHEVISQQGERFVDKYVDRKILKNKKSLLVIISLSVLSVVGFVLFYFTPNSR
KSDLFKNSSVENNNDDYIINSLLKSPNGKKFIVSKIDEALSFYDSKKNDINKYNEGNNNN
NADFKGLSLFKENTPSNNFIHNKDYFINFFDNKFLMNNAEHINQFYMFIKTNNKQYNSPN
EMKERFQVFLQNAHKVNMHNNNKNSLYKKELNRFADLTYHEFKNKYLSLRSSKPLKNSKY
LLDQMNYEEVIKKYRGEENFDHAAYDWRLHSGVTPVKDQKNCGSCWAFSSIGSVESQYAI
RKNKLITLSEQELVDCSFKNYGCNGGLINNAFEDMIELGGICPDGDYPYVSDAPNLCNID
RCTEKYGIKNYLSVPDNKLKEALRFLGPISISVAVSDDFAFYKEGIFDGECGDELNHAVM
LVGFGMKEIVNPLTKKGEKHYYYIIKNSWGQQWGERGFINIETDESGLMRKCGLGTDAFI
PLIE
|
|
|
|---|
| BDBM12041 |
|---|
| BDBM12033 |
|---|
| Name | BDBM12041 |
|---|
| Synonyms: | (2S)-2-({5-[(diaminomethylidene)amino]-1-oxopentan-2-yl}amino)-N-[(2S)-2-acetamido-4-methylpentanoyl]-4-methylpentanamide | Acetyl-Leu-Leu-Arg-CHO | Leupeptin (LEU) |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H38N6O4 |
|---|
| Mol. Mass. | 426.5535 |
|---|
| SMILES | CC(C)C[C@H](NC(CCCNC(N)=N)C=O)C(=O)NC(=O)[C@H](CC(C)C)NC(C)=O |r| |
|---|
| Structure | 
|
|---|
Search and Browse
