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TargetCaspase-1
LigandBDBM12047
Substrate/CompetitorCaspase-1 Fluorogenic Substrate
Meas. Tech.Caspase Inhibition Assay
pH7±n/a
Temperature310.15±n/a K
Ki 9400±n/a nM
Citation Shahripour, ABPlummer, MSLunney, EAAlbrecht, HPHays, SJKostlan, CRSawyer, TKWalker, NPBrady, KDAllen, HJTalanian, RVWong, WWHumblet, C Structure-based design of nonpeptide inhibitors of interleukin-1beta converting enzyme (ICE, caspase-1). Bioorg Med Chem10:31-40 (2002) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Caspase-1
Name:Caspase-1
Synonyms:CASP1 | CASP1_HUMAN | Caspase | Caspase 1 | ICE | IL1BC | IL1BCE | Interleukin-1 beta convertase | Interleukin-1 beta-converting enzyme
Type:Enzyme
Mol. Mass.:45154.13
Organism:Homo sapiens (Human)
Description:P29466
Residue:404
Sequence:
MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDS
VIPKGAQACQICITYICEEDSYLAGTLGLSADQTSGNYLNMQDSQGVLSSFPAPQAVQDN
PAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRT
GAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIR
EGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVG
VSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEY
ACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH
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  Blast E-value cutoff:
BDBM12047
Caspase-1 Fluorogenic Substrate
Name:Caspase-1 Fluorogenic Substrate
Synonyms:Ac-YVAD-AMC
Type:n/a
Mol. Mass.:1713.07
Organism:n/a
Description:AMC=7-Amino-4-methylcoumarin
Residue:17
Sequence:
Ac-Tyr-Val-Ala-Asp-AMC