Reaction Details |
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Target | Caspase-1 |
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Ligand | BDBM12068 |
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Substrate/Competitor | Caspase-1 Fluorogenic Substrate |
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Meas. Tech. | Caspase Inhibition Assay |
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pH | 7±n/a |
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Temperature | 310.15±n/a K |
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Ki | 880±n/a nM |
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Citation | Shahripour, AB; Plummer, MS; Lunney, EA; Sawyer, TK; Stankovic, CJ; Connolly, MK; Rubin, JR; Walker, NP; Brady, KD; Allen, HJ; Talanian, RV; Wong, WW; Humblet, C Structure-based design of caspase-1 inhibitor containing a diphenyl ether sulfonamide. Bioorg Med Chem Lett11:2779-82 (2001) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Caspase-1 |
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Name: | Caspase-1 |
Synonyms: | CASP1 | CASP1_HUMAN | Caspase | Caspase 1 | ICE | IL1BC | IL1BCE | Interleukin-1 beta convertase | Interleukin-1 beta-converting enzyme |
Type: | Enzyme |
Mol. Mass.: | 45154.13 |
Organism: | Homo sapiens (Human) |
Description: | P29466 |
Residue: | 404 |
Sequence: | MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDS
VIPKGAQACQICITYICEEDSYLAGTLGLSADQTSGNYLNMQDSQGVLSSFPAPQAVQDN
PAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRT
GAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIR
EGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVG
VSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEY
ACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH
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BDBM12068 |
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Caspase-1 Fluorogenic Substrate |
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Name: | Caspase-1 Fluorogenic Substrate |
Synonyms: | Ac-YVAD-AMC |
Type: | n/a |
Mol. Mass.: | 1713.07 |
Organism: | n/a |
Description: | AMC=7-Amino-4-methylcoumarin |
Residue: | 17 |
Sequence: | |