Reaction Details |
| Report a problem with these data |
Target | Dipeptidyl peptidase 8 |
---|
Ligand | BDBM12192 |
---|
Substrate/Competitor | BDBM11526 |
---|
Meas. Tech. | Enzyme Inhibition Assay |
---|
pH | 8±n/a |
---|
Temperature | 310.15±n/a K |
---|
IC50 | 24±n/a nM |
---|
Citation | Jiaang, WT; Chen, YS; Hsu, T; Wu, SH; Chien, CH; Chang, CN; Chang, SP; Lee, SJ; Chen, X Novel isoindoline compounds for potent and selective inhibition of prolyl dipeptidase DPP8. Bioorg Med Chem Lett15:687-91 (2005) [PubMed] Article |
---|
More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
---|
|
Dipeptidyl peptidase 8 |
---|
Name: | Dipeptidyl peptidase 8 |
Synonyms: | DPP8 | DPP8_HUMAN | DPRP-1 | DPRP1 | Dipeptidyl peptidase 8 (DPP-8) | Dipeptidyl peptidase 8 (DPP8) | Dipeptidyl peptidase 8/9 | Dipeptidyl peptidase IV-related protein 1 | Dipeptidyl peptidase VIII | Dipeptidyl peptidase VIII (DDP-VIII) | Prolyl dipeptidase DPP8 |
Type: | Enzyme |
Mol. Mass.: | 103342.62 |
Organism: | Homo sapiens (Human) |
Description: | Q6V1X1 |
Residue: | 898 |
Sequence: | MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQ
LKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPK
TINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLF
QAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISN
IVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILR
ILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVI
DKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVM
ERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLY
KITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYF
EGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLY
KLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGK
KYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKY
KMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAP
VTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAH
TSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI
|
|
|
BDBM12192 |
---|
BDBM11526 |
---|
Name | BDBM12192 |
Synonyms: | (2S)-2-amino-2-cyclohexyl-1-(2,3-dihydro-1H-isoindol-2-yl)ethan-1-one | US11096924, DASH-inhibitors 3360 | US11559537, Compound 3360-C | isoquinoline derivative 15 |
Type | Small organic molecule |
Emp. Form. | C16H22N2O |
Mol. Mass. | 258.3587 |
SMILES | N[C@@H](C1CCCCC1)C(=O)N1Cc2ccccc2C1 |r| |
Structure |
|