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TargetE3 ubiquitin-protein ligase SMURF1
LigandBDBM239110
Substrate/Competitorn/a
Meas. Tech.Pharmaceutical Assay
IC50 50.0±n/a nM
Citation Bala, KJBrearley, ADale, JEdwards, AAhmed, MPorter, DPulz, RARooney, LASandham, DAShaw, DSmith, NTaylor, JLTaylor, RJTroxler, TJWrigglesworth, J Carboxamide derivatives US Patent US10195181 Publication Date 2/5/2019
More Info.:Get all data from this article,  Assay Method
 
E3 ubiquitin-protein ligase SMURF1
Name:E3 ubiquitin-protein ligase SMURF1
Synonyms:E3 ubiquitin-protein ligase SMURF1 | HECT-type E3 ubiquitin transferase SMURF1 | KIAA1625 | SMAD ubiquitination regulatory factor 1 | SMAD-specific E3 ubiquitin-protein ligase 1 | SMUF1_HUMAN | SMURF1 | hSMURF1
Type:PROTEIN
Mol. Mass.:86120.64
Organism:Homo sapiens (Human)
Description:ChEMBL_116984
Residue:757
Sequence:
MSNPGTRRNGSSIKIRLTVLCAKNLAKKDFFRLPDPFAKIVVDGSGQCHSTDTVKNTLDP
KWNQHYDLYVGKTDSITISVWNHKKIHKKQGAGFLGCVRLLSNAISRLKDTGYQRLDLCK
LNPSDTDAVRGQIVVSLQTRDRIGTGGSVVDCRGLLENEGTVYEDSGPGRPLSCFMEEPA
PYTDSTGAAAGGGNCRFVESPSQDQRLQAQRLRNPDVRGSLQTPQNRPHGHQSPELPEGY
EQRTTVQGQVYFLHTQTGVSTWHDPRIPSPSGTIPGGDAAFLYEFLLQGHTSEPRDLNSV
NCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRLHHIMNHQCQLKEPSQPLPLPS
EGSLEDEELPAQRYERDLVQKLKVLRHELSLQQPQAGHCRIEVSREEIFEESYRQIMKMR
PKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSS
INPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLV
WILENDITPVLDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGI
EAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKHCVADSNIVR
WFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLP
KAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAVE
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  Blast E-value cutoff:
BDBM239110
n/a
NameBDBM239110
Synonyms:US10195181, Example 10 | US9403810, 10
TypeSmall organic molecule
Emp. Form.C22H32N4O3
Mol. Mass.400.5145
SMILESCc1c(onc1C(=O)Nc1c(C)n(C)n(C2CCCCC2)c1=O)C1CCCCC1
Structure
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