Reaction Details |
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Target | E3 ubiquitin-protein ligase SMURF1 |
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Ligand | BDBM239135 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Pharmaceutical Assay |
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IC50 | 250±n/a nM |
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Citation | Bala, KJ; Brearley, A; Dale, J; Edwards, A; Ahmed, M; Porter, D; Pulz, RA; Rooney, LA; Sandham, DA; Shaw, D; Smith, N; Taylor, JL; Taylor, RJ; Troxler, TJ; Wrigglesworth, J Carboxamide derivatives US Patent US10195181 Publication Date 2/5/2019 |
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More Info.: | Get all data from this article, Assay Method |
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E3 ubiquitin-protein ligase SMURF1 |
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Name: | E3 ubiquitin-protein ligase SMURF1 |
Synonyms: | E3 ubiquitin-protein ligase SMURF1 | HECT-type E3 ubiquitin transferase SMURF1 | KIAA1625 | SMAD ubiquitination regulatory factor 1 | SMAD-specific E3 ubiquitin-protein ligase 1 | SMUF1_HUMAN | SMURF1 | hSMURF1 |
Type: | PROTEIN |
Mol. Mass.: | 86120.64 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_116984 |
Residue: | 757 |
Sequence: | MSNPGTRRNGSSIKIRLTVLCAKNLAKKDFFRLPDPFAKIVVDGSGQCHSTDTVKNTLDP
KWNQHYDLYVGKTDSITISVWNHKKIHKKQGAGFLGCVRLLSNAISRLKDTGYQRLDLCK
LNPSDTDAVRGQIVVSLQTRDRIGTGGSVVDCRGLLENEGTVYEDSGPGRPLSCFMEEPA
PYTDSTGAAAGGGNCRFVESPSQDQRLQAQRLRNPDVRGSLQTPQNRPHGHQSPELPEGY
EQRTTVQGQVYFLHTQTGVSTWHDPRIPSPSGTIPGGDAAFLYEFLLQGHTSEPRDLNSV
NCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRLHHIMNHQCQLKEPSQPLPLPS
EGSLEDEELPAQRYERDLVQKLKVLRHELSLQQPQAGHCRIEVSREEIFEESYRQIMKMR
PKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSS
INPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLV
WILENDITPVLDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGI
EAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKHCVADSNIVR
WFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLP
KAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAVE
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BDBM239135 |
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n/a |
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Name | BDBM239135 |
Synonyms: | US10195181, Example 24b | US9403810, 24a |
Type | Small organic molecule |
Emp. Form. | C23H34N4O4 |
Mol. Mass. | 430.5405 |
SMILES | CC(C)[C@@H]1CO[C@H](C1)c1onc(C(=O)Nc2c(C)n(C)n(C3CCCCC3)c2=O)c1C |
Structure |
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