Reaction Details |
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Target | Hypoxia-inducible factor 1-alpha |
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Ligand | BDBM332048 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Stabilization of HIF-1alpha |
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EC50 | 530±20 nM |
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Citation | Li, S; Xiao, J; Wang, L; Long, L; Li, W; Luo, H; Li, F; Zhong, W; Zheng, Z; Xie, Y; Li, X; Zhou, X; Wang, X; Cao, R Substituted acethydrazide derivative, preparation method and use thereof US Patent US10196346 Publication Date 2/5/2019 |
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More Info.: | Get all data from this article, Assay Method |
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Hypoxia-inducible factor 1-alpha |
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Name: | Hypoxia-inducible factor 1-alpha |
Synonyms: | BHLHE78 | HIF-1-alpha | HIF-1-alpha, HIF-2-alpha | HIF1A | HIF1A_HUMAN | Hypoxia inducible factors | Hypoxia-inducible factor 1 alpha | Hypoxia-inducible factor 1-alpha | MOP1 | PASD8 | von Hippel-Lindau disease tumor suppressor/Elongin-C/Elongin-B/HIF1A |
Type: | Protein |
Mol. Mass.: | 92647.24 |
Organism: | Homo sapiens (Human) |
Description: | Q16665 |
Residue: | 826 |
Sequence: | MEGAGGANDKKKISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVM
RLTISYLRVRKLLDAGDLDIEDDMKAQMNCFYLKALDGFVMVLTDDGDMIYISDNVNKYM
GLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGLVKKGKEQNTQRSFFLRMKCTLTSRGR
TMNIKSATWKVLHCTGHIHVYDTNSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSK
TFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQV
TTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTECV
LKPVESSDMKMTQLFTKVESEDTSSLFDKLKKEPDALTLLAPAAGDTIISLDFGSNDTET
DDQQLEEVPLYNDVMLPSPNEKLQNINLAMSPLPTAETPKPLRSSADPALNQEVALKLEP
NPESLELSFTMPQIQDQTPSPSDGSTRQSSPEPNSPSEYCFYVDSDMVNEFKLELVEKLF
AEDTEAKNPFSTQDTDLDLEMLAPYIPMDDDFQLRSFDQLSPLESSSASPESASPQSTVT
VFQQTQIQEPTANATTTTATTDELKTVTKDRMEDIKILIASPSPTHIHKETTSATSSPYR
DTQSRTASPNRAGKGVIEQTEKSHPRSPNVLSVALSQRTTVPEEELNPKILALQNAQRKR
KMEHDGSLFQAVGIGTLLQQPDDHAATTSLSWKRVKGCKSSEQNGMEQKTIILIPSDLAC
RLLGQSMDESGLPQLTSYDCEVNAPIQGSRNLLQGEELLRALDQVN
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BDBM332048 |
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n/a |
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Name | BDBM332048 |
Synonyms: | (E)-N'-(4-N,N-diethylamino- 2-hydroxybenzal)-2-{N-{2- [N-(4-cyanobenzyl)-N- methylamino]ethyl}N- methylamino}acethydrazide | US10196346, Example 30 |
Type | Small organic molecule |
Emp. Form. | C25H34N6O2 |
Mol. Mass. | 450.5765 |
SMILES | CCN(CC)c1ccc(\C=N\NC(=O)CN(C)CCN(C)Cc2ccc(cc2)C#N)c(O)c1 |
Structure |
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