Reaction Details |
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Target | Hypoxia-inducible factor 1-alpha |
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Ligand | BDBM332050 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Stabilization of HIF-1alpha |
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EC50 | 1860±570 nM |
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Citation | Li, S; Xiao, J; Wang, L; Long, L; Li, W; Luo, H; Li, F; Zhong, W; Zheng, Z; Xie, Y; Li, X; Zhou, X; Wang, X; Cao, R Substituted acethydrazide derivative, preparation method and use thereof US Patent US10196346 Publication Date 2/5/2019 |
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More Info.: | Get all data from this article, Assay Method |
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Hypoxia-inducible factor 1-alpha |
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Name: | Hypoxia-inducible factor 1-alpha |
Synonyms: | BHLHE78 | HIF-1-alpha | HIF-1-alpha, HIF-2-alpha | HIF1A | HIF1A_HUMAN | Hypoxia inducible factors | Hypoxia-inducible factor 1 alpha | Hypoxia-inducible factor 1-alpha | MOP1 | PASD8 | von Hippel-Lindau disease tumor suppressor/Elongin-C/Elongin-B/HIF1A |
Type: | Protein |
Mol. Mass.: | 92647.24 |
Organism: | Homo sapiens (Human) |
Description: | Q16665 |
Residue: | 826 |
Sequence: | MEGAGGANDKKKISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVM
RLTISYLRVRKLLDAGDLDIEDDMKAQMNCFYLKALDGFVMVLTDDGDMIYISDNVNKYM
GLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGLVKKGKEQNTQRSFFLRMKCTLTSRGR
TMNIKSATWKVLHCTGHIHVYDTNSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSK
TFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQV
TTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTECV
LKPVESSDMKMTQLFTKVESEDTSSLFDKLKKEPDALTLLAPAAGDTIISLDFGSNDTET
DDQQLEEVPLYNDVMLPSPNEKLQNINLAMSPLPTAETPKPLRSSADPALNQEVALKLEP
NPESLELSFTMPQIQDQTPSPSDGSTRQSSPEPNSPSEYCFYVDSDMVNEFKLELVEKLF
AEDTEAKNPFSTQDTDLDLEMLAPYIPMDDDFQLRSFDQLSPLESSSASPESASPQSTVT
VFQQTQIQEPTANATTTTATTDELKTVTKDRMEDIKILIASPSPTHIHKETTSATSSPYR
DTQSRTASPNRAGKGVIEQTEKSHPRSPNVLSVALSQRTTVPEEELNPKILALQNAQRKR
KMEHDGSLFQAVGIGTLLQQPDDHAATTSLSWKRVKGCKSSEQNGMEQKTIILIPSDLAC
RLLGQSMDESGLPQLTSYDCEVNAPIQGSRNLLQGEELLRALDQVN
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BDBM332050 |
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n/a |
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Name | BDBM332050 |
Synonyms: | (E)-N'-(3-ethoxy-2- hydroxybenzal)-2-{N-{2-[N- (4-tert-butylbenzyl)-N- methylamino]ethyl}N- methylamino}acethydrazide | US10196346, Example 32 |
Type | Small organic molecule |
Emp. Form. | C26H38N4O3 |
Mol. Mass. | 454.6049 |
SMILES | CCOc1cccc(\C=N\NC(=O)CN(C)CCN(C)Cc2ccc(cc2)C(C)(C)C)c1O |
Structure |
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