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TargetHypoxia-inducible factor 1-alpha
LigandBDBM332051
Substrate/Competitorn/a
Meas. Tech.Stabilization of HIF-1alpha
EC50 130±20 nM
Citation Li, SXiao, JWang, LLong, LLi, WLuo, HLi, FZhong, WZheng, ZXie, YLi, XZhou, XWang, XCao, R Substituted acethydrazide derivative, preparation method and use thereof US Patent US10196346 Publication Date 2/5/2019
More Info.:Get all data from this article,  Assay Method
 
Hypoxia-inducible factor 1-alpha
Name:Hypoxia-inducible factor 1-alpha
Synonyms:BHLHE78 | HIF-1-alpha | HIF-1-alpha, HIF-2-alpha | HIF1A | HIF1A_HUMAN | Hypoxia inducible factors | Hypoxia-inducible factor 1 alpha | Hypoxia-inducible factor 1-alpha | MOP1 | PASD8 | von Hippel-Lindau disease tumor suppressor/Elongin-C/Elongin-B/HIF1A
Type:Protein
Mol. Mass.:92647.24
Organism:Homo sapiens (Human)
Description:Q16665
Residue:826
Sequence:
MEGAGGANDKKKISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVM
RLTISYLRVRKLLDAGDLDIEDDMKAQMNCFYLKALDGFVMVLTDDGDMIYISDNVNKYM
GLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGLVKKGKEQNTQRSFFLRMKCTLTSRGR
TMNIKSATWKVLHCTGHIHVYDTNSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSK
TFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQV
TTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTECV
LKPVESSDMKMTQLFTKVESEDTSSLFDKLKKEPDALTLLAPAAGDTIISLDFGSNDTET
DDQQLEEVPLYNDVMLPSPNEKLQNINLAMSPLPTAETPKPLRSSADPALNQEVALKLEP
NPESLELSFTMPQIQDQTPSPSDGSTRQSSPEPNSPSEYCFYVDSDMVNEFKLELVEKLF
AEDTEAKNPFSTQDTDLDLEMLAPYIPMDDDFQLRSFDQLSPLESSSASPESASPQSTVT
VFQQTQIQEPTANATTTTATTDELKTVTKDRMEDIKILIASPSPTHIHKETTSATSSPYR
DTQSRTASPNRAGKGVIEQTEKSHPRSPNVLSVALSQRTTVPEEELNPKILALQNAQRKR
KMEHDGSLFQAVGIGTLLQQPDDHAATTSLSWKRVKGCKSSEQNGMEQKTIILIPSDLAC
RLLGQSMDESGLPQLTSYDCEVNAPIQGSRNLLQGEELLRALDQVN
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BDBM332051
n/a
NameBDBM332051
Synonyms:(E)-N'-(4-N,N-diethylamino- 2-hydroxybenzal)-2-{N-{3- [N-(4-tert-butylbenzyl)-N- methylamino]propyl}N- methylamino}acethydrazide | US10196346, Example 33
TypeSmall organic molecule
Emp. Form.C29H45N5O2
Mol. Mass.495.6999
SMILESCCN(CC)c1ccc(\C=N\NC(=O)CN(C)CCCN(C)Cc2ccc(cc2)C(C)(C)C)c(O)c1
Structure
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