| Reaction Details |
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 | Report a problem with these data |
| Target | Proteasome subunit alpha type-6 |
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| Ligand | BDBM67544 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Proteasome Activity Assay |
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| pH | 7.5±n/a |
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| Temperature | 310.15±n/a K |
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| EC50 | 7800±0.0 nM |
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| Comments | extracted |
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| Citation |  Jones, CL; Njomen, E; Sjögren, B; Dexheimer, TS; Tepe, JJ Small Molecule Enhancement of 20S Proteasome Activity Targets Intrinsically Disordered Proteins. ACS Chem Biol12:2240-2247 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Proteasome subunit alpha type-6 |
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| Name: | Proteasome subunit alpha type-6 |
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| Synonyms: | 27 kDa prosomal protein | Macropain iota chain | Multicatalytic endopeptidase complex iota chain | PROS-27 | PROS27 | PSA6_HUMAN | PSMA6 | Proteasome iota chain | p27K |
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| Type: | PROTEIN |
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| Mol. Mass.: | 27399.66 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_106197 |
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| Residue: | 246 |
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| Sequence: | MSRGSSAGFDRHITIFSPEGRLYQVEYAFKAINQGGLTSVAVRGKDCAVIVTQKKVPDKL
LDSSTVTHLFKITENIGCVMTGMTADSRSQVQRARYEAANWKYKYGYEIPVDMLCKRIAD
ISQVYTQNAEMRPLGCCMILIGIDEEQGPQVYKCDPAGYYCGFKATAAGVKQTESTSFLE
KKVKKKFDWTFEQTVETAITCLSTVLSIDFKPSEIEVGVVTVENPKFRILTEAEIDAHLV
ALAERD
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| BDBM67544 |
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| n/a |
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| Name | BDBM67544 |
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| Synonyms: | N,N-dimethyl-3-[2-(trifluoromethyl)-10-phenothiazinyl]-1-propanamine;hydrochloride | N,N-dimethyl-3-[2-(trifluoromethyl)phenothiazin-10-yl]propan-1-amine;hydrochloride | SR-01000000224-4 | TRIFLUPROMAZINE | cid_66069 | dimethyl-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]amine;hydrochloride | med.21724, Compound Triflupromazine |
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| Type | Small organic molecule |
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| Emp. Form. | C18H19F3N2S |
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| Mol. Mass. | 352.417 |
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| SMILES | CN(C)CCCN1c2ccccc2Sc2ccc(cc12)C(F)(F)F |
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| Structure | 
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