| Reaction Details |
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 | Report a problem with these data |
| Target | G-protein coupled receptor 183 |
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| Ligand | BDBM332551 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Cell-Based Luminescent Assay |
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| IC50 | <5±n/a nM |
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| Citation |  Pinkerton, AB; Ardecky, R; Sergienko, EA; Gonzalez-Lopez, M; Ganji, SR; Zou, J Spirocyclic EBI2 modulators US Patent US10196369 Publication Date 2/5/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| G-protein coupled receptor 183 |
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| Name: | G-protein coupled receptor 183 |
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| Synonyms: | EBI2 | GP183_HUMAN | GPR183 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 41245.79 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_108311 |
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| Residue: | 361 |
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| Sequence: | MDIQMANNFTPPSATPQGNDCDLYAHHSTARIVMPLHYSLVFIIGLVGNLLALVVIVQNR
KKINSTTLYSTNLVISDILFTTALPTRIAYYAMGFDWRIGDALCRITALVFYINTYAGVN
FMTCLSIDRFIAVVHPLRYNKIKRIEHAKGVCIFVWILVFAQTLPLLINPMSKQEAERIT
CMEYPNFEETKSLPWILLGACFIGYVLPLIIILICYSQICCKLFRTAKQNPLTEKSGVNK
KALNTIILIIVVFVLCFTPYHVAIIQHMIKKLRFSNFLECSQRHSFQISLHFTVCLMNFN
CCMDPFIYFFACKGYKRKVMRMLKRQVSVSISSAVKSAPEENSREMTETQMMIHSKSSNG
K
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| BDBM332551 |
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| n/a |
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| Name | BDBM332551 |
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| Synonyms: | (2E)-3-(4-bromophenyl)-1-{2-[(4-chlorophenyl)methyl]-2,7-diazaspiro[3.5]non-7-yl}prop-2-en-1-one | US10196369, Compound C6 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H24BrClN2O |
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| Mol. Mass. | 459.806 |
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| SMILES | Clc1ccc(CN2CC3(C2)CCN(CC3)C(=O)\C=C\c2ccc(Br)cc2)cc1 |
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| Structure | 
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