| Reaction Details |
|---|
 | Report a problem with these data |
| Target | G-protein coupled receptor 183 |
|---|
| Ligand | BDBM332588 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Cell-Based Luminescent Assay |
|---|
| IC50 | <5±n/a nM |
|---|
| Citation |  Pinkerton, AB; Ardecky, R; Sergienko, EA; Gonzalez-Lopez, M; Ganji, SR; Zou, J Spirocyclic EBI2 modulators US Patent US10196369 Publication Date 2/5/2019 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| G-protein coupled receptor 183 |
|---|
| Name: | G-protein coupled receptor 183 |
|---|
| Synonyms: | EBI2 | GP183_HUMAN | GPR183 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 41245.79 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_108311 |
|---|
| Residue: | 361 |
|---|
| Sequence: | MDIQMANNFTPPSATPQGNDCDLYAHHSTARIVMPLHYSLVFIIGLVGNLLALVVIVQNR
KKINSTTLYSTNLVISDILFTTALPTRIAYYAMGFDWRIGDALCRITALVFYINTYAGVN
FMTCLSIDRFIAVVHPLRYNKIKRIEHAKGVCIFVWILVFAQTLPLLINPMSKQEAERIT
CMEYPNFEETKSLPWILLGACFIGYVLPLIIILICYSQICCKLFRTAKQNPLTEKSGVNK
KALNTIILIIVVFVLCFTPYHVAIIQHMIKKLRFSNFLECSQRHSFQISLHFTVCLMNFN
CCMDPFIYFFACKGYKRKVMRMLKRQVSVSISSAVKSAPEENSREMTETQMMIHSKSSNG
K
|
|
|
|---|
| BDBM332588 |
|---|
| n/a |
|---|
| Name | BDBM332588 |
|---|
| Synonyms: | 4-({2-[(2E)-3-(4-bromophenyl)prop-2-enoyl]-2,7-diazaspiro[3.5]non-7-yl}carbonyl)-2-fluorobenzenecarbonitrile | US10196369, Compound C43 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H21BrFN3O2 |
|---|
| Mol. Mass. | 482.345 |
|---|
| SMILES | Fc1cc(ccc1C#N)C(=O)N1CCC2(CN(C2)C(=O)\C=C\c2ccc(Br)cc2)CC1 |
|---|
| Structure | 
|
|---|
Search and Browse
