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Reaction Details
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TargetCoagulation factor X
LigandBDBM12574
Substrate/CompetitorBDBM12500
Meas. Tech.Factor Xa Inhibition Assay
pH7.8±n/a
Temperature298.15±n/a K
Ki 16±n/a nM
Citation Watson, NSBrown, DCampbell, MChan, CChaudry, LConvery, MAFenwick, RHamblin, JNHaslam, CKelly, HAKing, NPKurtis, CLLeach, ARManchee, GRMason, AMMitchell, CPatel, CPatel, VKSenger, SShah, GPWeston, HEWhitworth, CYoung, RJ Design and synthesis of orally active pyrrolidin-2-one-based factor Xa inhibitors. Bioorg Med Chem Lett16:3784-8 (2006) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Coagulation factor X
Name:Coagulation factor X
Synonyms:Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor
Type:Enzyme
Mol. Mass.:54726.60
Organism:Homo sapiens (Human)
Description:n/a
Residue:488
Sequence:
MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE
TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN
CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR
KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE
CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE
AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI
VSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSG
GPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPE
VITSSPLK
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM12574
BDBM12500
NameBDBM12574
Synonyms:6-chloro-N-[(3R)-2-oxo-1-[(2S)-1-oxo-1-(piperidin-1-yl)propan-2-yl]pyrrolidin-3-yl]naphthalene-2-sulfonamide | pyrrolidin-2-one-based inhibitor 36
TypeSmall organic molecule
Emp. Form.C22H26ClN3O4S
Mol. Mass.463.978
SMILESC[C@H](N1CC[C@@H](NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O)C(=O)N1CCCCC1 |r|
Structure
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