Reaction Details |
| Report a problem with these data |
Target | Dipeptidyl peptidase 9 |
---|
Ligand | BDBM12644 |
---|
Substrate/Competitor | BDBM11057 |
---|
Meas. Tech. | DPPIV Inhibition Assay |
---|
Ki | 3300±n/a nM |
---|
Citation | Madar, DJ; Kopecka, H; Pireh, D; Yong, H; Pei, Z; Li, X; Wiedeman, PE; Djuric, SW; Von Geldern, TW; Fickes, MG; Bhagavatula, L; McDermott, T; Wittenberger, S; Richards, SJ; Longenecker, KL; Stewart, KD; Lubben, TH; Ballaron, SJ; Stashko, MA; Long, MA; Wells, H; Zinker, BA; Mika, AK; Beno, DW; Kempf-Grote, AJ; Polakowski, J; Segreti, J; Reinhart, GA; Fryer, RM; Sham, HL; Trevillyan, JM Discovery of 2-[4-{{2-(2S,5R)-2-cyano-5-ethynyl-1-pyrrolidinyl]-2-oxoethyl]amino]-4-methyl-1-piperidinyl]-4-pyridinecarboxylic acid (ABT-279): a very potent, selective, effective, and well-tolerated inhibitor of dipeptidyl peptidase-IV, useful for the treatment of diabetes. J Med Chem49:6416-20 (2006) [PubMed] Article |
---|
More Info.: | Get all data from this article, Solution Info, Assay Method |
---|
|
Dipeptidyl peptidase 9 |
---|
Name: | Dipeptidyl peptidase 9 |
Synonyms: | DPP9 | DPP9_HUMAN | DPRP-2 | DPRP2 | Dipeptidyl peptidase 9 (DDP9) | Dipeptidyl peptidase 9 (DPP-9) | Dipeptidyl peptidase 9 (DPP9) | Dipeptidyl peptidase IV-related protein 2 | Dipeptidyl peptidase IX | Dipeptidyl peptidase IX (DDP-IX) | Dipeptidyl peptidase-like protein 9 |
Type: | Enzyme |
Mol. Mass.: | 98260.70 |
Organism: | Homo sapiens (Human) |
Description: | Q86TI2 |
Residue: | 863 |
Sequence: | MATTGTPTADRGDAAATDDPAARFQVQKHSWDGLRSIIHGSRKYSGLIVNKAPHDFQFVQ
KTDESGPHSHRLYYLGMPYGSRENSLLYSEIPKKVRKEALLLLSWKQMLDHFQATPHHGV
YSREEELLRERKRLGVFGITSYDFHSESGLFLFQASNSLFHCRDGGKNGFMVSPMKPLEI
KTQCSGPRMDPKICPADPAFFSFINNSDLWVANIETGEERRLTFCHQGLSNVLDDPKSAG
VATFVIQEEFDRFTGYWWCPTASWEGSEGLKTLRILYEEVDESEVEVIHVPSPALEERKT
DSYRYPRTGSKNPKIALKLAEFQTDSQGKIVSTQEKELVQPFSSLFPKVEYIARAGWTRD
GKYAWAMFLDRPQQWLQLVLLPPALFIPSTENEEQRLASARAVPRNVQPYVVYEEVTNVW
INVHDIFYPFPQSEGEDELCFLRANECKTGFCHLYKVTAVLKSQGYDWSEPFSPGEDEFK
CPIKEEIALTSGEWEVLARHGSKIWVNEETKLVYFQGTKDTPLEHHLYVVSYEAAGEIVR
LTTPGFSHSCSMSQNFDMFVSHYSSVSTPPCVHVYKLSGPDDDPLHKQPRFWASMMEAAS
CPPDYVPPEIFHFHTRSDVRLYGMIYKPHALQPGKKHPTVLFVYGGPQVQLVNNSFKGIK
YLRLNTLASLGYAVVVIDGRGSCQRGLRFEGALKNQMGQVEIEDQVEGLQFVAEKYGFID
LSRVAIHGWSYGGFLSLMGLIHKPQVFKVAIAGAPVTVWMAYDTGYTERYMDVPENNQHG
YEAGSVALHVEKLPNEPNRLLILHGFLDENVHFFHTNFLVSQLIRAGKPYQLQIYPNERH
SIRCPESGEHYEVTLLHFLQEYL
|
|
|
BDBM12644 |
---|
BDBM11057 |
---|
Name | BDBM12644 |
Synonyms: | (2S)-1-[2-(tert-butylamino)acetyl]pyrrolidine-2-carbonitrile | CHEMBL96937 | Cyanopyrrolidine 38 |
Type | Small organic molecule |
Emp. Form. | C11H19N3O |
Mol. Mass. | 209.2881 |
SMILES | CC(C)(C)NCC(=O)N1CCC[C@H]1C#N |r| |
Structure |
|