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TargetSerine protease 1
LigandBDBM12659
Substrate/CompetitorBDBM12679
Meas. Tech.Enzyme Assay and Determination of the Inhibition Constants.
Ki>5200±n/a nM
Citation Quan, MLLam, PYHan, QPinto, DJHe, MYLi, REllis, CDClark, CGTeleha, CASun, JHAlexander, RSBai, SLuettgen, JMKnabb, RMWong, PCWexler, RR Discovery of 1-(3'-aminobenzisoxazol-5'-yl)-3-trifluoromethyl-N-[2-fluoro-4-[(2'-dimethylaminomethyl)imidazol-1-yl]phenyl]-1H-pyrazole-5-carboxyamide hydrochloride (razaxaban), a highly potent, selective, and orally bioavailable factor Xa inhibitor. J Med Chem48:1729-44 (2005) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Serine protease 1
Name:Serine protease 1
Synonyms:Beta-Trypsin | Cationic trypsin | PRSS1 | TRP1 | TRY1 | TRY1_BOVIN | TRYP1 | Trypsin | Trypsin I
Type:Enzyme
Mol. Mass.:25790.52
Organism:Bos taurus (bovine)
Description:P00760
Residue:246
Sequence:
MKTFIFLALLGAAVAFPVDDDDKIVGGYTCGANTVPYQVSLNSGYHFCGGSLINSQWVVS
AAHCYKSGIQVRLGEDNINVVEGNEQFISASKSIVHPSYNSNTLNNDIMLIKLKSAASLN
SRVASISLPTSCASAGTQCLISGWGNTKSSGTSYPDVLKCLKAPILSDSSCKSAYPGQIT
SNMFCAGYLEGGKDSCQGDSGGPVVCSGKLQGIVSWGSGCAQKNKPGVYTKVCNYVSWIK
QTIASN
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  Blast E-value cutoff:
BDBM12659
BDBM12679
NameBDBM12659
Synonyms:1-(3-Aminobenzisoxazol-5-yl)-3-trifluoromethyl-5-[(2-methylsulfonyl-3-fluoro[1,1]biphen-4-yl)aminocarbonyl]-pyrazole, Trifluoroacetic Acid | 1-(3-amino-1,2-benzoxazol-5-yl)-N-[2-fluoro-4-(2-methanesulfonylphenyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide; 2,2,2-trifluoroacetic acid | CHEMBL554926 | Razaxaban Analogue | aminobenzisoxazole 38
TypeSmall organic molecule
Emp. Form.C25H17F4N5O4S
Mol. Mass.559.492
SMILESCS(=O)(=O)c1ccccc1-c1ccc(NC(=O)c2cc(nn2-c2ccc3onc(N)c3c2)C(F)(F)F)c(F)c1
Structure
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