| Reaction Details |
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 | Report a problem with these data |
| Target | Coagulation factor IX |
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| Ligand | BDBM12764 |
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| Substrate/Competitor | BDBM12774 |
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| Meas. Tech. | Enzyme Assay and Determination of the Inhibition Constants. |
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| Ki | 26±n/a nM |
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| Citation |  Smallheer, JM; Alexander, RS; Wang, J; Wang, S; Nakajima, S; Rossi, KA; Smallwood, A; Barbera, F; Burdick, D; Luettgen, JM; Knabb, RM; Wexler, RR; Jadhav, PK SAR and factor IXa crystal structure of a dual inhibitor of factors IXa and Xa. Bioorg Med Chem Lett14:5263-7 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Coagulation factor IX |
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| Name: | Coagulation factor IX |
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| Synonyms: | Christmas factor | Coagulation factor IX precursor | Coagulation factor IX/VIII | Coagulation factor IXa | Coagulation factor IXa heavy chain | Coagulation factor IXa light chain | F9 | FA9_HUMAN | Factor IX | Factor IXa | Factor IXa (fIXa) | PTC | Plasma thromboplastin component |
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| Type: | Enzyme |
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| Mol. Mass.: | 51768.83 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P00740 |
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| Residue: | 461 |
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| Sequence: | MQRVNMIMAESPGLITICLLGYLLSAECTVFLDHENANKILNRPKRYNSGKLEEFVQGNL
ERECMEEKCSFEEAREVFENTERTTEFWKQYVDGDQCESNPCLNGGSCKDDINSYECWCP
FGFEGKNCELDVTCNIKNGRCEQFCKNSADNKVVCSCTEGYRLAENQKSCEPAVPFPCGR
VSVSQTSKLTRAETVFPDVDYVNSTEAETILDNITQSTQSFNDFTRVVGGEDAKPGQFPW
QVVLNGKVDAFCGGSIVNEKWIVTAAHCVETGVKITVVAGEHNIEETEHTEQKRNVIRII
PHHNYNAAINKYNHDIALLELDEPLVLNSYVTPICIADKEYTNIFLKFGSGYVSGWGRVF
HKGRSALVLQYLRVPLVDRATCLRSTKFTIYNNMFCAGFHEGGRDSCQGDSGGPHVTEVE
GTSFLTGIISWGEECAMKGKYGIYTKVSRYVNWIKEKTKLT
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| BDBM12764 |
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| BDBM12774 |
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| Name | BDBM12764 |
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| Synonyms: | 1-(3-carbamimidoylphenyl)-N-[4-(5,6-dichloro-1H-1,3-benzodiazol-1-yl)-2-fluorophenyl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide | pyrazole analog 3m |
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| Type | Small organic molecule |
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| Emp. Form. | C25H15Cl2F4N7O |
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| Mol. Mass. | 576.333 |
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| SMILES | NC(=N)c1cccc(c1)-n1nc(cc1C(=O)Nc1ccc(cc1F)-n1cnc2cc(Cl)c(Cl)cc12)C(F)(F)F |
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| Structure | 
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