Reaction Details |
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Target | Coagulation factor IX |
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Ligand | BDBM12782 |
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Substrate/Competitor | BDBM12774 |
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Meas. Tech. | Enzyme Assay and Determination of the Inhibition Constants. |
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Ki | 160±n/a nM |
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Citation | Batt, DG; Qiao, JX; Modi, DP; Houghton, GC; Pierson, DA; Rossi, KA; Luettgen, JM; Knabb, RM; Jadhav, PK; Wexler, RR 5-Amidinoindoles as dual inhibitors of coagulation factors IXa and Xa. Bioorg Med Chem Lett14:5269-73 (2004) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Coagulation factor IX |
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Name: | Coagulation factor IX |
Synonyms: | Christmas factor | Coagulation factor IX precursor | Coagulation factor IX/VIII | Coagulation factor IXa | Coagulation factor IXa heavy chain | Coagulation factor IXa light chain | F9 | FA9_HUMAN | Factor IX | Factor IXa | Factor IXa (fIXa) | PTC | Plasma thromboplastin component |
Type: | Enzyme |
Mol. Mass.: | 51768.83 |
Organism: | Homo sapiens (Human) |
Description: | P00740 |
Residue: | 461 |
Sequence: | MQRVNMIMAESPGLITICLLGYLLSAECTVFLDHENANKILNRPKRYNSGKLEEFVQGNL
ERECMEEKCSFEEAREVFENTERTTEFWKQYVDGDQCESNPCLNGGSCKDDINSYECWCP
FGFEGKNCELDVTCNIKNGRCEQFCKNSADNKVVCSCTEGYRLAENQKSCEPAVPFPCGR
VSVSQTSKLTRAETVFPDVDYVNSTEAETILDNITQSTQSFNDFTRVVGGEDAKPGQFPW
QVVLNGKVDAFCGGSIVNEKWIVTAAHCVETGVKITVVAGEHNIEETEHTEQKRNVIRII
PHHNYNAAINKYNHDIALLELDEPLVLNSYVTPICIADKEYTNIFLKFGSGYVSGWGRVF
HKGRSALVLQYLRVPLVDRATCLRSTKFTIYNNMFCAGFHEGGRDSCQGDSGGPHVTEVE
GTSFLTGIISWGEECAMKGKYGIYTKVSRYVNWIKEKTKLT
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BDBM12782 |
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BDBM12774 |
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Name | BDBM12782 |
Synonyms: | 5-amidinoindole 16 | N-[4-(1H-1,3-benzodiazol-1-yl)phenyl]-2-(5-carbamimidoyl-1H-indol-3-yl)butanamide |
Type | Small organic molecule |
Emp. Form. | C26H24N6O |
Mol. Mass. | 436.5084 |
SMILES | CCC(C(=O)Nc1ccc(cc1)-n1cnc2ccccc12)c1c[nH]c2ccc(cc12)C(N)=N |
Structure |
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