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TargetDimer of Gag-Pol polyprotein [491-589,Q498K,D521N,V555I,N579D]
LigandBDBM578
Substrate/CompetitorHIV-1 Protease Substrate
Meas. Tech.Enzyme Inhibition Assay
Ki 0.04±n/a nM
Citation Ali, AReddy, GSCao, HAnjum, SGNalam, MNSchiffer, CARana, TM Discovery of HIV-1 protease inhibitors with picomolar affinities incorporating N-aryl-oxazolidinone-5-carboxamides as novel P2 ligands. J Med Chem49:7342-56 (2006) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Dimer of Gag-Pol polyprotein [491-589,Q498K,D521N,V555I,N579D]
Name:Dimer of Gag-Pol polyprotein [491-589,Q498K,D521N,V555I,N579D]
Synonyms:HIV-1 Protease Mutant M2 (D30N, L63P, N88D)
Type:Protein Complex
Mol. Mass.:n/a
Description:n/a
Components:This complex has 2 components.
Component 1
Name:Gag-Pol polyprotein [491-589,Q498K,D521N,V555I,N579D]
Synonyms:HIV-1 Protease Mutant M2 (D30N, L63P, N88D) chain A | HIV-1 Protease Mutant M2 (D30N, L63P, N88D) chain B | POL_HV1A2 | gag-pol
Type:Enzyme Subunit
Mol. Mass.:10807.22
Organism:Human immunodeficiency virus type 1
Description:P03369[491-589,Q498K,D521N,V555I,N579D]
Residue:99
Sequence:
PQITLWKRPLVTIRIGGQLKEALLDTGADNTVLEEMNLPGKWKPKMIGGIGGFIKVRQYD
QIPIEICGHKAIGTVLVGPTPVNIIGRDLLTQIGCTLNF
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
Component 2
Name:Gag-Pol polyprotein [491-589,Q498K,D521N,V555I,N579D]
Synonyms:HIV-1 Protease Mutant M2 (D30N, L63P, N88D) chain A | HIV-1 Protease Mutant M2 (D30N, L63P, N88D) chain B | POL_HV1A2 | gag-pol
Type:Enzyme Subunit
Mol. Mass.:10807.22
Organism:Human immunodeficiency virus type 1
Description:P03369[491-589,Q498K,D521N,V555I,N579D]
Residue:99
Sequence:
PQITLWKRPLVTIRIGGQLKEALLDTGADNTVLEEMNLPGKWKPKMIGGIGGFIKVRQYD
QIPIEICGHKAIGTVLVGPTPVNIIGRDLLTQIGCTLNF
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM578
HIV-1 Protease Substrate
Name:HIV-1 Protease Substrate
Synonyms:n/a
Type:Peptide
Mol. Mass.:4728.18
Organism:n/a
Description:n/a
Residue:44
Sequence:
Arg-Glu(EDANS)-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-Lys(DABCYL)-

Arg