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TargetPhenylethanolamine N-methyltransferase
LigandBDBM13016
Substrate/CompetitorBDBM13015
Meas. Tech.Radiochemical Assay of PNMT Inhibitors
pH8±n/a
Temperature310.15±n/a K
Ki 5800±500 nM
Citation Grunewald, GLSeim, MRRegier, RCMartin, JLGee, CLDrinkwater, NCriscione, KR Comparison of the binding of 3-fluoromethyl-7-sulfonyl-1,2,3,4-tetrahydroisoquinolines with their isosteric sulfonamides to the active site of phenylethanolamine N-methyltransferase. J Med Chem49:5424-33 (2006) [PubMed]  Article
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Phenylethanolamine N-methyltransferase
Name:Phenylethanolamine N-methyltransferase
Synonyms:Noradrenaline N-methyltransferase | PENT | PNMT | PNMT_HUMAN | PNMTase | Phenylethanolamine N-Methyltransferase (PNMT)
Type:Enzyme
Mol. Mass.:30852.66
Organism:Homo sapiens (Human)
Description:n/a
Residue:282
Sequence:
MSGADRSPNAGAAPDSAPGQAAVASAYQRFEPRAYLRNNYAPPRGDLCNPNGVGPWKLRC
LAQTFATGEVSGRTLIDIGSGPTVYQLLSACSHFEDITMTDFLEVNRQELGRWLQEEPGA
FNWSMYSQHACLIEGKGECWQDKERQLRARVKRVLPIDVHQPQPLGAGSPAPLPADALVS
AFCLEAVSPDLASFQRALDHITTLLRPGGHLLLIGALEESWYLAGEARLTVVPVSEEEVR
EALVRSGYKVRDLRTYIMPAHLQTGVDDVKGVFFAWAQKVGL
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  Blast E-value cutoff:
BDBM13016
BDBM13015
NameBDBM13016
Synonyms:1,2,3,4-tetrahydroisoquinoline | CHEMBL14346 | THIQ 6 | tetrahydroisoquinoline
TypeSmall organic molecule
Emp. Form.C9H11N
Mol. Mass.133.1903
SMILESC1Cc2ccccc2CN1
Structure
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