| Reaction Details |
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 | Report a problem with these data |
| Target | Phenylethanolamine N-methyltransferase |
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| Ligand | BDBM13027 |
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| Substrate/Competitor | BDBM13015 |
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| Meas. Tech. | Radiochemical Assay of PNMT Inhibitors |
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| pH | 8±n/a |
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| Temperature | 310.15±n/a K |
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| Ki | 23±2 nM |
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| Citation |  Grunewald, GL; Seim, MR; Regier, RC; Martin, JL; Gee, CL; Drinkwater, N; Criscione, KR Comparison of the binding of 3-fluoromethyl-7-sulfonyl-1,2,3,4-tetrahydroisoquinolines with their isosteric sulfonamides to the active site of phenylethanolamine N-methyltransferase. J Med Chem49:5424-33 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Phenylethanolamine N-methyltransferase |
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| Name: | Phenylethanolamine N-methyltransferase |
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| Synonyms: | Noradrenaline N-methyltransferase | PENT | PNMT | PNMT_HUMAN | PNMTase | Phenylethanolamine N-Methyltransferase (PNMT) |
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| Type: | Enzyme |
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| Mol. Mass.: | 30852.66 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 282 |
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| Sequence: | MSGADRSPNAGAAPDSAPGQAAVASAYQRFEPRAYLRNNYAPPRGDLCNPNGVGPWKLRC
LAQTFATGEVSGRTLIDIGSGPTVYQLLSACSHFEDITMTDFLEVNRQELGRWLQEEPGA
FNWSMYSQHACLIEGKGECWQDKERQLRARVKRVLPIDVHQPQPLGAGSPAPLPADALVS
AFCLEAVSPDLASFQRALDHITTLLRPGGHLLLIGALEESWYLAGEARLTVVPVSEEEVR
EALVRSGYKVRDLRTYIMPAHLQTGVDDVKGVFFAWAQKVGL
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| BDBM13027 |
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| BDBM13015 |
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| Name | BDBM13027 |
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| Synonyms: | 3-(hydroxymethyl)-N-(2,2,2-trifluoroethyl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide | 7-sulfonamide-THIQ 17 | CHEMBL366785 |
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| Type | Small organic molecule |
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| Emp. Form. | C12H15F3N2O3S |
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| Mol. Mass. | 324.319 |
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| SMILES | OCC1Cc2ccc(cc2CN1)S(=O)(=O)NCC(F)(F)F |
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| Structure | 
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