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TargetSerine protease 1
LigandBDBM13282
Substrate/CompetitorBDBM12500
Meas. Tech.Enzyme Assay and Determination of the Inhibition Constants.
pH7.5±n/a
Temperature295.15±n/a K
Ki 704±n/a nM
Citation Choi-Sledeski, YMMcGarry, DGGreen, DMMason, HJBecker, MRDavis, RSEwing, WRDankulich, WPManetta, VEMorris, RLSpada, APCheney, DLBrown, KDColussi, DJChu, VHeran, CLMorgan, SRBentley, RGLeadley, RJMaignan, SGuilloteau, JPDunwiddie, CTPauls, HW Sulfonamidopyrrolidinone factor Xa inhibitors: potency and selectivity enhancements via P-1 and P-4 optimization. J Med Chem42:3572-87 (1999) [PubMed]  Article
More Info.:Get all data from this article,  Inhibition_Run data,   Solution Info,  Assay Method
 
Serine protease 1
Name:Serine protease 1
Synonyms:Beta-Trypsin | Cationic trypsin | PRSS1 | TRP1 | TRY1 | TRY1_BOVIN | TRYP1 | Trypsin | Trypsin I
Type:Enzyme
Mol. Mass.:25790.52
Organism:Bos taurus (bovine)
Description:P00760
Residue:246
Sequence:
MKTFIFLALLGAAVAFPVDDDDKIVGGYTCGANTVPYQVSLNSGYHFCGGSLINSQWVVS
AAHCYKSGIQVRLGEDNINVVEGNEQFISASKSIVHPSYNSNTLNNDIMLIKLKSAASLN
SRVASISLPTSCASAGTQCLISGWGNTKSSGTSYPDVLKCLKAPILSDSSCKSAYPGQIT
SNMFCAGYLEGGKDSCQGDSGGPVVCSGKLQGIVSWGSGCAQKNKPGVYTKVCNYVSWIK
QTIASN
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BDBM13282
BDBM12500
NameBDBM13282
Synonyms:3-{[(3S)-3-[(7-methoxynaphthalene-2-)(methyl)sulfonamido]-2-oxopyrrolidin-1-yl]methyl}benzene-1-carboximidamide | CHEMBL333678 | Sulfonamidopyrrolidinone 3b
TypeSmall organic molecule
Emp. Form.C24H26N4O4S
Mol. Mass.466.553
SMILESCOc1ccc2ccc(cc2c1)S(=O)(=O)N(C)[C@H]1CCN(Cc2cccc(c2)C(N)=N)C1=O |r|
Structure
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