Reaction Details |
| Report a problem with these data |
Target | ATP-dependent RNA helicase RhlE |
---|
Ligand | BDBM13319 |
---|
Substrate/Competitor | biotinylated lamin B peptide substrate |
---|
Meas. Tech. | PfPFT and Rat PFT IC50 Determination |
---|
pH | 7.5±n/a |
---|
Temperature | 310.15±n/a K |
---|
IC50 | 0.9±n/a nM |
---|
Citation | Nallan, L; Bauer, KD; Bendale, P; Rivas, K; Yokoyama, K; Horney, CP; Pendyala, PR; Floyd, D; Lombardo, LJ; Williams, DK; Hamilton, A; Sebti, S; Windsor, WT; Weber, PC; Buckner, FS; Chakrabarti, D; Gelb, MH; Van Voorhis, WC Protein farnesyltransferase inhibitors exhibit potent antimalarial activity. J Med Chem48:3704-13 (2005) [PubMed] Article |
---|
More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
---|
|
ATP-dependent RNA helicase RhlE |
---|
Name: | ATP-dependent RNA helicase RhlE |
Synonyms: | Protein Farnesyltransferase (PFT) | Protein prenyltransferase, alpha subunit |
Type: | Enzyme |
Mol. Mass.: | 54781.31 |
Organism: | Plasmodium falciparum (malaria parasite P. falciparum) |
Description: | Q5E175 |
Residue: | 500 |
Sequence: | MGFTSLGLSAPILKAVEEQGYSTPSPIQLQAIPAVIEGKDVMAAAQTGTGKTAGFTLPLL
ERLSNGPKRKFNQVRALVLTPTRELAAQVHESVEKYSKNLPLTSDVVFGGVKVNPQMQRL
RRGVDVLVATPGRLLDLANQNAIKFDQLEILVLDEADRMLDMGFIHDIKKILAKLPKNRQ
NLLFSATFSDEIRQLAKGLVKDPVEISVAKRNTTAETVEQSVYVMDKGRKPKVLTKLIKD
NDWKQVLVFSKTKHGANRLAKTLEEKGVSAAAIHGNKSQGARTKALANFKSGQVRVLVAT
DIAARGLDIEQLPQVINVDLPKVPEDYVHRIGRTGRAGATGKAISFVSEDEAKELFAIER
LIQKVLPRHVLEGFEPVNKVPESKLDTRPIKPKKPKKPKAPRVEHKDGQRSGENRNGNKQ
GAKQGQKPATKRTPTNNPSGKKEGTDSDKKKRPFSGKPKTKGTGENRGNGSNFGKSKSTP
KSDVKPRRQGPRPARKPKAN
|
|
|
BDBM13319 |
---|
biotinylated lamin B peptide substrate |
---|
Name: | biotinylated lamin B peptide substrate |
Synonyms: | n/a |
Type: | Peptide |
Mol. Mass.: | 1715.01 |
Organism: | n/a |
Description: | A human lamin-B carboxy-terminus sequence peptide (biotin-YRASNRSCAIM) is 3H-farnesylated at the cysteine residue when processed by farnesyltransferase. |
Residue: | 15 |
Sequence: | |