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TargetProtein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
LigandBDBM13390
Substrate/CompetitorK-ras(B) decapeptide
Meas. Tech.Enzyme Inhibition Assay
IC50 0.19±n/a nM
Citation Wang, LWang, GTWang, XTong, YSullivan, GPark, DLeonard, NMLi, QCohen, JGu, WZZhang, HBauch, JLJakob, CGHutchins, CWStoll, VSMarsh, KRosenberg, SHSham, HLLin, NH Design, synthesis, and biological activity of 4-[(4-cyano-2-arylbenzyloxy)-(3-methyl-3H-imidazol-4-yl)methyl]benzonitriles as potent and selective farnesyltransferase inhibitors. J Med Chem47:612-26 (2004) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
Name:Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
Synonyms:CAAX farnesyltransferase alpha subunit | FNTA | FNTA_HUMAN | FTase-1-alpha | FTase-alpha | GGTase-I-alpha | Geranylgeranyl Transferase (GGTase-I) Chain A | Geranylgeranyl transferase type I | Protein Farnesyltransferase (PFT) Chain A | Protein farnesyl/geranylgeranyl transferase | Protein farnesyltransferase | Protein farnesyltransferase subunit alpha | Protein farnesyltransferase/geranylgeranyltransferase type I alpha subunit | Ras proteins prenyltransferase alpha
Type:Enzyme
Mol. Mass.:44392.46
Organism:Homo sapiens (Human)
Description:Recombinant human FTase.
Residue:379
Sequence:
MAATEGVGEAAQGGEPGQPAQPPPQPHPPPPQQQHKEEMAAEAGEAVASPMDDGFVSLDS
PSYVLYRDRAEWADIDPVPQNDGPNPVVQIIYSDKFRDVYDYFRAVLQRDERSERAFKLT
RDAIELNAANYTVWHFRRVLLKSLQKDLHEEMNYITAIIEEQPKNYQVWHHRRVLVEWLR
DPSQELEFIADILNQDAKNYHAWQHRQWVIQEFKLWDNELQYVDQLLKEDVRNNSVWNQR
YFVISNTTGYNDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSKYPNLLNQLL
DLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIG
RSLQSKHSTENDSPTNVQQ
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM13390
K-ras(B) decapeptide
Name:K-ras(B) decapeptide
Synonyms:biotin conjugated K-ras decapeptide
Type:Peptide
Mol. Mass.:1611.07
Organism:n/a
Description:n/a
Residue:14
Sequence:
biotin-KKSKTKCVIM