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TargetGeranylgeranyl transferase type-1 subunit beta
LigandBDBM13390
Substrate/CompetitorK-ras(B) decapeptide
Meas. Tech.Enzyme Inhibition Assay
IC50 1800±n/a nM
Citation Wang, L; Wang, GT; Wang, X; Tong, Y; Sullivan, G; Park, D; Leonard, NM; Li, Q; Cohen, J; Gu, WZ; Zhang, H; Bauch, JL; Jakob, CG; Hutchins, CW; Stoll, VS; Marsh, K; Rosenberg, SH; Sham, HL; Lin, NH Design, synthesis, and biological activity of 4-[(4-cyano-2-arylbenzyloxy)-(3-methyl-3H-imidazol-4-yl)methyl]benzonitriles as potent and selective farnesyltransferase inhibitors. J Med Chem47:612-26 (2004) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Geranylgeranyl transferase type-1 subunit beta
Name:Geranylgeranyl transferase type-1 subunit beta
Synonyms:GGTase-I-beta | Geranylgeranyl transferase type I | Geranylgeranyl transferase type-1 subunit beta | PGGT1B | PGTB1_BOVIN | Type I protein geranyl-geranyltransferase subunit beta
Type:Enzyme
Mol. Mass.:42483.88
Organism:Bos taurus (bovine)
Description:Purified from bovine brain
Residue:377
Sequence:
MAATEDERPTGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDM
LDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKNPGTAHPYDSG
HIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASC
ICYMLNNWSGMDMKKAINYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVF
SEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILS
TQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLRDLHQS
WKTKDSKQCSENVHIST
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM13390
K-ras(B) decapeptide
Name:K-ras(B) decapeptide
Synonyms:biotin conjugated K-ras decapeptide
Type:Peptide
Mol. Mass.:1611.07
Organism:n/a
Description:n/a
Residue:14
Sequence:
biotin-KKSKTKCVIM