Reaction Details |
| Report a problem with these data |
Target | Histone-lysine N-methyltransferase EZH2 |
---|
Ligand | BDBM335714 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | Histone Methyl Transferase Assay |
---|
EC50 | <5000±n/a nM |
---|
Citation | Kim, KS; Zhang, L; Purandare, AV; Seitz, SP Inhibitors of lysine methyl transferase US Patent US9738630 Publication Date 8/22/2017 |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Histone-lysine N-methyltransferase EZH2 |
---|
Name: | Histone-lysine N-methyltransferase EZH2 |
Synonyms: | ENX-1 | EZH2 | EZH2_HUMAN | Enhancer of zeste homolog 2 (EZH2) | Histone-lysine N-methyltransferase EZH2 | KMT6 | Lysine N-methyltransferase 6 |
Type: | Protein |
Mol. Mass.: | 85367.84 |
Organism: | Homo sapiens (Human) |
Description: | Q15910 |
Residue: | 746 |
Sequence: | MGQTGKKSEKGPVCWRKRVKSEYMRLRQLKRFRRADEVKSMFSSNRQKILERTEILNQEW
KQRRIQPVHILTSVSSLRGTRECSVTSDLDFPTQVIPLKTLNAVASVPIMYSWSPLQQNF
MVEDETVLHNIPYMGDEVLDQDGTFIEELIKNYDGKVHGDRECGFINDEIFVELVNALGQ
YNDDDDDDDGDDPEEREEKQKDLEDHRDDKESRPPRKFPSDKIFEAISSMFPDKGTAEEL
KEKYKELTEQQLPGALPPECTPNIDGPNAKSVQREQSLHSFHTLFCRRCFKYDCFLHPFH
ATPNTYKRKNTETALDNKPCGPQCYQHLEGAKEFAAALTAERIKTPPKRPGGRRRGRLPN
NSSRPSTPTINVLESKDTDSDREAGTETGGENNDKEEEEKKDETSSSSEANSRCQTPIKM
KPNIEPPENVEWSGAEASMFRVLIGTYYDNFCAIARLIGTKTCRQVYEFRVKESSIIAPA
PAEDVDTPPRKKKRKHRLWAAHCRKIQLKKDGSSNHVYNYQPCDHPRQPCDSSCPCVIAQ
NFCEKFCQCSSECQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWDSKNVS
CKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDK
YMCSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQTGE
ELFFDYRYSQADALKYVGIEREMEIP
|
|
|
BDBM335714 |
---|
n/a |
---|
Name | BDBM335714 |
Synonyms: | US9738630, Example 9 | tert-Butyl 4-(5-(1-(sec-butyl)-3- methyl-4-(((1-methyl-3-oxo-2,3- dihydroisoquinolin-4-yl)methyl) carbamoyl)-1H-indol-6-yl)pyridin- 2-yl)piperazine-1-carboxylate |
Type | Small organic molecule |
Emp. Form. | C39H46N6O4 |
Mol. Mass. | 662.8203 |
SMILES | CCC(C)n1cc(C)c2c(cc(cc12)-c1ccc(nc1)N1CCN(CC1)C(=O)OC(C)(C)C)C(=O)NCc1c2ccccc2c(C)[nH]c1=O |
Structure |
|