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TargetHistone-lysine N-methyltransferase EZH2
LigandBDBM335716
Substrate/Competitorn/a
Meas. Tech.Histone Methyl Transferase Assay
EC50<5000±n/a nM
Citation Kim, KSZhang, LPurandare, AVSeitz, SP Inhibitors of lysine methyl transferase US Patent US9738630 Publication Date 8/22/2017
More Info.:Get all data from this article,  Assay Method
 
Histone-lysine N-methyltransferase EZH2
Name:Histone-lysine N-methyltransferase EZH2
Synonyms:ENX-1 | EZH2 | EZH2_HUMAN | Enhancer of zeste homolog 2 (EZH2) | Histone-lysine N-methyltransferase EZH2 | KMT6 | Lysine N-methyltransferase 6
Type:Protein
Mol. Mass.:85367.84
Organism:Homo sapiens (Human)
Description:Q15910
Residue:746
Sequence:
MGQTGKKSEKGPVCWRKRVKSEYMRLRQLKRFRRADEVKSMFSSNRQKILERTEILNQEW
KQRRIQPVHILTSVSSLRGTRECSVTSDLDFPTQVIPLKTLNAVASVPIMYSWSPLQQNF
MVEDETVLHNIPYMGDEVLDQDGTFIEELIKNYDGKVHGDRECGFINDEIFVELVNALGQ
YNDDDDDDDGDDPEEREEKQKDLEDHRDDKESRPPRKFPSDKIFEAISSMFPDKGTAEEL
KEKYKELTEQQLPGALPPECTPNIDGPNAKSVQREQSLHSFHTLFCRRCFKYDCFLHPFH
ATPNTYKRKNTETALDNKPCGPQCYQHLEGAKEFAAALTAERIKTPPKRPGGRRRGRLPN
NSSRPSTPTINVLESKDTDSDREAGTETGGENNDKEEEEKKDETSSSSEANSRCQTPIKM
KPNIEPPENVEWSGAEASMFRVLIGTYYDNFCAIARLIGTKTCRQVYEFRVKESSIIAPA
PAEDVDTPPRKKKRKHRLWAAHCRKIQLKKDGSSNHVYNYQPCDHPRQPCDSSCPCVIAQ
NFCEKFCQCSSECQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWDSKNVS
CKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDK
YMCSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQTGE
ELFFDYRYSQADALKYVGIEREMEIP
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  Blast E-value cutoff:
BDBM335716
n/a
NameBDBM335716
Synonyms:N-((6,8-Difluoro-1-methyl-3-oxo- 2,3-dihydroisoquinolin-4- yl)methyl)-5-(ethyl(tetrahydro- 2H-pyran-4-yl)amino)-4-methyl- 4'-(morpholinomethyl)-[1,1'- biphenyl]-3-carboxamide | US9738630, Example 11
TypeSmall organic molecule
Emp. Form.C37H42F2N4O4
Mol. Mass.644.7506
SMILESCCN(C1CCOCC1)c1cc(cc(C(=O)NCc2c3cc(F)cc(F)c3c(C)[nH]c2=O)c1C)-c1ccc(CN2CCOCC2)cc1
Structure
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