Ki Summary

Reaction Details

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Target

Histamine receptor H3

Ligand

BDBM200822

Substrate/Competitor

n/a

Meas. Tech.

Radioligand binding assay

267±0 nM

Citation

Gao, Z; Hall, D; Stefany, D Substituted N-heteroaryl spirolactam bipyrrolidines, preparation and therapeutic use thereof US Patent US9533995 Publication Date 1/3/2017

More Info.:

Get all data from this article, Assay Method

Histamine receptor H3

Name:

Histamine receptor H3

Synonyms:

n/a

Type:

Enzyme

Mol. Mass.:

48611.84

Organism:

Macaca mulatta (Rhesus macaque)

Description:

Q865E1

Residue:

445

Sequence:

MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFV
ADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTS
SAFNIVLISYDRFLSVTRAVSYRAQQGNTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGG
SSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAG
GPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAAGAEAGETALGGGGGGGSA
ASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSL
AVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFR
RAFTKLLCPQKLKIQPHSSLEQCWK

BDBM200822

n/a

Name

BDBM200822

Synonyms:

8-hydroxy-2-[2-methyl-6-((2s,3'r)-2-methyl-[1,3']bipyrrolidinyl-1'-yl)-pyridin-3-yl]-2-aza-spiro[4.5]decan-1-one | US9533995, 5

Type

Small organic molecule

Emp. Form.

C24H36N4O2

Mol. Mass.

412.5682

SMILES

C[C@H]1CCCN1[C@@H]1CCN(C1)c1ccc(N2CCC3(CCC(O)CC3)C2=O)c(C)n1 |r,wU:6.6,wD:1.0,(5.66,-3.46,;6.99,-2.69,;8.46,-3.17,;9.36,-1.92,;8.46,-.68,;6.99,-1.15,;5.66,-.38,;5.66,1.16,;4.2,1.63,;3.29,.38,;4.2,-.86,;1.75,.38,;.98,-.95,;-.56,-.95,;-1.33,.38,;-2.99,.38,;-3.9,-.86,;-5.36,-.39,;-5.36,1.15,;-5.36,2.69,;-6.7,3.46,;-8.03,2.69,;-9.36,3.46,;-8.03,1.15,;-6.7,.38,;-3.9,1.63,;-3.13,2.96,;-.56,1.72,;-1.33,3.05,;.98,1.72,)|

Structure