| Reaction Details |
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 | Report a problem with these data |
| Target | Histamine receptor H3 |
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| Ligand | BDBM200834 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Radioligand binding assay |
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| Ki | 105±0 nM |
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| Citation |  Gao, Z; Hall, D; Stefany, D Substituted N-heteroaryl spirolactam bipyrrolidines, preparation and therapeutic use thereof US Patent US9533995 Publication Date 1/3/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Histamine receptor H3 |
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| Name: | Histamine receptor H3 |
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| Synonyms: | n/a |
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| Type: | Enzyme |
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| Mol. Mass.: | 48611.84 |
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| Organism: | Macaca mulatta (Rhesus macaque) |
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| Description: | Q865E1 |
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| Residue: | 445 |
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| Sequence: | MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFV
ADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTS
SAFNIVLISYDRFLSVTRAVSYRAQQGNTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGG
SSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAG
GPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAAGAEAGETALGGGGGGGSA
ASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSL
AVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFR
RAFTKLLCPQKLKIQPHSSLEQCWK
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| BDBM200834 |
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| n/a |
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| Name | BDBM200834 |
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| Synonyms: | 2-[5-((2s,3's)-2-methyl-[1,3']bipyrrolidinyl-1'-yl)-pyrazin-2-yl]-1-oxo-2,8-diaza-spiro[4.5]decane-8-carboxylic acid tert-butyl ester | US9533995, 14 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H40N6O3 |
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| Mol. Mass. | 484.6342 |
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| SMILES | C[C@H]1CCCN1[C@H]1CCN(C1)c1cnc(cn1)N1CCC2(CCN(CC2)C(=O)OC(C)(C)C)C1=O |r| |
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| Structure | 
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