| Reaction Details |
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 | Report a problem with these data |
| Target | cGMP-dependent protein kinase 2 |
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| Ligand | BDBM65502 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Microfluidic Mobility-Shift Assay |
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| pH | 7±n/a |
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| EC50 | 58±5.0 nM |
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| Comments | extracted |
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| Citation |  Campbell, JC; Henning, P; Franz, E; Sankaran, B; Herberg, FW; Kim, C Structural Basis of Analog Specificity in PKG I and II. ACS Chem Biol12:2388-2398 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| cGMP-dependent protein kinase 2 |
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| Name: | cGMP-dependent protein kinase 2 |
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| Synonyms: | CGK 2 | KGP2_HUMAN | PRKG2 | PRKGR2 | Type II cGMP-dependent protein kinase | cGKII |
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| Type: | PROTEIN |
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| Mol. Mass.: | 87448.25 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_774533 |
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| Residue: | 762 |
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| Sequence: | MGNGSVKPKHSKHPDGHSGNLTTDALRNKVTELERELRRKDAEIQEREYHLKELREQLSK
QTVAIAELTEELQNKCIQLNKLQDVVHMQGGSPLQASPDKVPLEVHRKTSGLVSLHSRRG
AKAGVSAEPTTRTYDLNKPPEFSFEKARVRKDSSEKKLITDALNKNQFLKRLDPQQIKDM
VECMYGRNYQQGSYIIKQGEPGNHIFVLAEGRLEVFQGEKLLSSIPMWTTFGELAILYNC
TRTASVKAITNVKTWALDREVFQNIMRRTAQARDEQYRNFLRSVSLLKNLPEDKLTKIID
CLEVEYYDKGDYIIREGEEGSTFFILAKGKVKVTQSTEGHDQPQLIKTLQKGEYFGEKAL
ISDDVRSANIIAEENDVACLVIDRETFNQTVGTFEELQKYLEGYVANLNRDDEKRHAKRS
MSNWKLSKALSLEMIQLKEKVARFSSSSPFQNLEIIATLGVGGFGRVELVKVKNENVAFA
MKCIRKKHIVDTKQQEHVYSEKRILEELCSPFIVKLYRTFKDNKYVYMLLEACLGGELWS
ILRDRGSFDEPTSKFCVACVTEAFDYLHRLGIIYRDLKPENLILDAEGYLKLVDFGFAKK
IGSGQKTWTFCGTPEYVAPEVILNKGHDFSVDFWSLGILVYELLTGNPPFSGVDQMMTYN
LILKGIEKMDFPRKITRRPEDLIRRLCRQNPTERLGNLKNGINDIKKHRWLNGFNWEGLK
ARSLPSPLQRELKGPIDHSYFDKYPPEKGMPPDELSGWDKDF
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| BDBM65502 |
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| n/a |
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| Name | BDBM65502 |
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| Synonyms: | 2-amino-8-bromo-9-[(2R,4aR,6R,7R,7aS)-2,7-dihydroxy-2-oxotetrahydro-2H,4H-2lambda~5~-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl]-1,9-dihydro-6H-purin-6-one | 8-Br-cGMP |
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| Type | Small organic molecule |
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| Emp. Form. | C10H11BrN5O7P |
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| Mol. Mass. | 424.101 |
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| SMILES | Nc1nc2n([C@@H]3O[C@@H]4COP(O)(=O)O[C@H]4[C@H]3O)c(Br)nc2c(=O)[nH]1 |
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| Structure | 
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