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TargetIntermediate conductance calcium-activated potassium channel protein 4
LigandBDBM200905
Substrate/Competitorn/a
Meas. Tech.KCa3.1 Assay
IC50 39±0 nM
Citation Burke, MJMcKibben, BTschantz, MA Fused thiazin-3-ones as KCA3.1 inhibitors US Patent US9533999 Publication Date 1/3/2017
More Info.:Get all data from this article,  Assay Method
 
Intermediate conductance calcium-activated potassium channel protein 4
Name:Intermediate conductance calcium-activated potassium channel protein 4
Synonyms:IK1 | IKCA1 | KCA4 | KCNN4 | KCNN4_HUMAN | Putative Gardos channel | SK4
Type:PROTEIN
Mol. Mass.:47723.22
Organism:Homo sapiens (Human)
Description:ChEMBL_1361891
Residue:427
Sequence:
MGGDLVLGLGALRRRKRLLEQEKSLAGWALVLAGTGIGLMVLHAEMLWFGGCSWALYLFL
VKCTISISTFLLLCLIVAFHAKEVQLFMTDNGLRDWRVALTGRQAAQIVLELVVCGLHPA
PVRGPPCVQDLGAPLTSPQPWPGFLGQGEALLSLAMLLRLYLVPRAVLLRSGVLLNASYR
SIGALNQVRFRHWFVAKLYMNTHPGRLLLGLTLGLWLTTAWVLSVAERQAVNATGHLSDT
LWLIPITFLTIGYGDVVPGTMWGKIVCLCTGVMGVCCTALLVAVVARKLEFNKAEKHVHN
FMMDIQYTKEMKESAARVLQEAWMFYKHTRRKESHAARRHQRKLLAAINAFRQVRLKHRK
LREQVNSMVDISKMHMILYDLQQNLSSSHRALEKQIDTLAGKLDALTELLSTALGPRQLP
EPSQQSK
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  Blast E-value cutoff:
BDBM200905
n/a
NameBDBM200905
Synonyms:US9533999, i-39
TypeSmall organic molecule
Emp. Form.C14H9F4NO4S2
Mol. Mass.395.349
SMILESFc1ccc(CN2c3sccc3S(=O)(=O)CC2=O)cc1OC(F)(F)F
Structure
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