| Reaction Details |
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 | Report a problem with these data |
| Target | Intermediate conductance calcium-activated potassium channel protein 4 |
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| Ligand | BDBM200937 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | KCa3.1 Assay |
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| IC50 | 46±0 nM |
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| Citation |  Burke, MJ; McKibben, B; Tschantz, MA Fused thiazin-3-ones as KCA3.1 inhibitors US Patent US9533999 Publication Date 1/3/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Intermediate conductance calcium-activated potassium channel protein 4 |
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| Name: | Intermediate conductance calcium-activated potassium channel protein 4 |
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| Synonyms: | IK1 | IKCA1 | KCA4 | KCNN4 | KCNN4_HUMAN | Putative Gardos channel | SK4 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 47723.22 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1361891 |
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| Residue: | 427 |
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| Sequence: | MGGDLVLGLGALRRRKRLLEQEKSLAGWALVLAGTGIGLMVLHAEMLWFGGCSWALYLFL
VKCTISISTFLLLCLIVAFHAKEVQLFMTDNGLRDWRVALTGRQAAQIVLELVVCGLHPA
PVRGPPCVQDLGAPLTSPQPWPGFLGQGEALLSLAMLLRLYLVPRAVLLRSGVLLNASYR
SIGALNQVRFRHWFVAKLYMNTHPGRLLLGLTLGLWLTTAWVLSVAERQAVNATGHLSDT
LWLIPITFLTIGYGDVVPGTMWGKIVCLCTGVMGVCCTALLVAVVARKLEFNKAEKHVHN
FMMDIQYTKEMKESAARVLQEAWMFYKHTRRKESHAARRHQRKLLAAINAFRQVRLKHRK
LREQVNSMVDISKMHMILYDLQQNLSSSHRALEKQIDTLAGKLDALTELLSTALGPRQLP
EPSQQSK
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| BDBM200937 |
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| n/a |
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| Name | BDBM200937 |
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| Synonyms: | US9533999, ii-5 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H10ClF3N2OS |
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| Mol. Mass. | 358.766 |
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| SMILES | FC(F)(F)c1cc(CN2C(=O)CSc3cccnc23)ccc1Cl |
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| Structure | 
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