Reaction Details |
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Target | Tyrosine-protein kinase ABL1 [201-500,F359V] |
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Ligand | BDBM13530 |
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Substrate/Competitor | BDBM13531 |
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Meas. Tech. | Kinase Assay and Binding Constant Measurement |
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pH | 7.4±n/a |
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Temperature | 298.15±n/a K |
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Kd | 20±n/a nM |
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Citation | Carter, TA; Wodicka, LM; Shah, NP; Velasco, AM; Fabian, MA; Treiber, DK; Milanov, ZV; Atteridge, CE; Biggs, WH; Edeen, PT; Floyd, M; Ford, JM; Grotzfeld, RM; Herrgard, S; Insko, DE; Mehta, SA; Patel, HK; Pao, W; Sawyers, CL; Varmus, H; Zarrinkar, PP; Lockhart, DJ Inhibition of drug-resistant mutants of ABL, KIT, and EGF receptor kinases. Proc Natl Acad Sci U S A102:11011-6 (2005) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Tyrosine-protein kinase ABL1 [201-500,F359V] |
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Name: | Tyrosine-protein kinase ABL1 [201-500,F359V] |
Synonyms: | ABL | ABL Mutant (F359V) | ABL1 | ABL1_HUMAN | JTK7 | Proto-oncogene tyrosine-protein kinase ABL1 mutant F359V | c-ABL | p150 |
Type: | Enzyme |
Mol. Mass.: | 34547.72 |
Organism: | Homo sapiens (Human) |
Description: | P00519[201-500,F359V] |
Residue: | 300 |
Sequence: | HHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGV
WKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTY
GNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNVIHRDLAARNCLVGENHLVKVA
DFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPY
PGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQES
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BDBM13530 |
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BDBM13531 |
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Name | BDBM13530 |
Synonyms: | 4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide | CHEMBL941 | Gleevec | Imatinib | Imatinib, 21 | N-(4-methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}phenyl)-4-[(4-methylpiperazin-1-yl)methyl]benzamide | STI-571 | STI571 | US10906896, Cpd imatinib | US11649218, Example Imatinib | US11725005, Compound imatinib | US9255107, Imatinib | cid_5291 | imatinib-CD3 | med.21724, Compound 6 |
Type | Small organic molecule |
Emp. Form. | C29H31N7O |
Mol. Mass. | 493.6027 |
SMILES | CN1CCN(Cc2ccc(cc2)C(=O)Nc2ccc(C)c(Nc3nccc(n3)-c3cccnc3)c2)CC1 |
Structure |
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