Ki Summary

Reaction Details

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Target

Tyrosine-protein kinase ABL1 [201-500,H396P]

Ligand

BDBM13216

Substrate/Competitor

BDBM13531

Meas. Tech.

Kinase Assay and Binding Constant Measurement

1±n/a nM

Citation

Carter, TA; Wodicka, LM; Shah, NP; Velasco, AM; Fabian, MA; Treiber, DK; Milanov, ZV; Atteridge, CE; Biggs, WH; Edeen, PT; Floyd, M; Ford, JM; Grotzfeld, RM; Herrgard, S; Insko, DE; Mehta, SA; Patel, HK; Pao, W; Sawyers, CL; Varmus, H; Zarrinkar, PP; Lockhart, DJ Inhibition of drug-resistant mutants of ABL, KIT, and EGF receptor kinases. Proc Natl Acad Sci U S A102:11011-6 (2005) [PubMed] Article

More Info.:

Get all data from this article, Solution Info, Assay Method

Tyrosine-protein kinase ABL1 [201-500,H396P]

Name:

Tyrosine-protein kinase ABL1 [201-500,H396P]

Synonyms:

ABL | ABL Mutant (H396P) | ABL1 | ABL1_HUMAN | JTK7 | Proto-oncogene tyrosine-protein kinase ABL1 mutant H396P | c-ABL | p150

Type:

Enzyme

Mol. Mass.:

34555.23

Organism:

Homo sapiens (Human)

Description:

P00519[201-500,H396P]

Residue:

300

Sequence:

HHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGV
WKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTY
GNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVA
DFGLSRLMTGDTYTAPAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPY
PGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQES

BDBM13216

BDBM13531

Name

BDBM13216

Synonyms:

BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl)]-2-methyl-4-pyrimidinyl]amino)]-1,3-thiazole-5-carboxamide | N-(2-chloro-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamide | US10294227, Code Dasatinib | US20230348453, Compound A8 | cid_3062316 | med.21724, Compound Dasatinib

Type

Small organic molecule

Emp. Form.

C22H26ClN7O2S

Mol. Mass.

488.006

SMILES

Cc1nc(Nc2ncc(s2)C(=O)Nc2c(C)cccc2Cl)cc(n1)N1CCN(CCO)CC1

Structure