| Reaction Details |
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 | Report a problem with these data |
| Target | Aurora kinase C |
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| Ligand | BDBM13534 |
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| Substrate/Competitor | Not Specified |
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| Meas. Tech. | In Vitro Kinase Assay |
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| pH | 7.5±n/a |
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| Temperature | 295.15±n/a K |
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| Ki | 4.6±n/a nM |
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| Citation |  Harrington, EA; Bebbington, D; Moore, J; Rasmussen, RK; Ajose-Adeogun, AO; Nakayama, T; Graham, JA; Demur, C; Hercend, T; Diu-Hercend, A; Su, M; Golec, JM; Miller, KM VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo. Nat Med10:262-7 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Aurora kinase C |
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| Name: | Aurora kinase C |
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| Synonyms: | AIE2 | AIK3 | AIRK3 | ARK3 | AURKC | AURKC_HUMAN | Aurora Kinase C (Aurora-C) | Aurora kinase C | Aurora kinase C (AURKC) | Aurora-C | Aurora-C/INCENP | Aurora/Ipl1-related kinase 3 | Aurora/Ipl1/Eg2 protein 2 | STK13 | Serine/threonine-protein kinase 13 | Serine/threonine-protein kinase Aurora-C |
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| Type: | Enzyme |
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| Mol. Mass.: | 35602.43 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Amino acid residues 1-309 were expressed as His-tagged fusion protein using baculovirus expression system. |
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| Residue: | 309 |
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| Sequence: | MSSPRAVVQLGKAQPAGEELATANQTAQQPSSPAMRRLTVDDFEIGRPLGKGKFGNVYLA
RLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQHPNILRLYNYFHDARRVYLIL
EYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHDKKVIHRDIKPENLLLGFRGEV
KIADFGWSVHTPSLRRKTMCGTLDYLPPEMIEGRTYDEKVDLWCIGVLCYELLVGYPPFE
SASHSETYRRILKVDVRFPLSMPLGARDLISRLLRYQPLERLPLAQILKHPWVQAHSRRV
LPPCAQMAS
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|
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| BDBM13534 |
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| Not Specified |
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| Name: | Not Specified |
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| Synonyms: | n/a |
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| Type: | n/a |
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| Mol. Mass.: | 358.43 |
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| Organism: | n/a |
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| Description: | n/a |
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| Residue: | 3 |
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| Sequence: | |
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