| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Coagulation factor VII |
|---|
| Ligand | BDBM13564 |
|---|
| Substrate/Competitor | BDBM13553 |
|---|
| Meas. Tech. | Serine Protease Inhibition Assay |
|---|
| pH | 7.8±n/a |
|---|
| Temperature | 295.15±n/a K |
|---|
| Ki | 180±n/a nM |
|---|
| Citation |  Zbinden, KG; Obst-Sander, U; Hilpert, K; Kuhne, H; Banner, DW; Bohm, HJ; Stahl, M; Ackermann, J; Alig, L; Weber, L; Wessel, HP; Riederer, MA; Tschopp, TB; Lave, T Selective and orally bioavailable phenylglycine tissue factor/factor VIIa inhibitors. Bioorg Med Chem Lett15:5344-52 (2005) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Solution Info, Assay Method |
|---|
| |
| Coagulation factor VII |
|---|
| Name: | Coagulation factor VII |
|---|
| Synonyms: | Eptacog alfa | F7 | FA7_HUMAN | Factor VIIa | Factor VIIa (fVIIa) | Proconvertin | SPCA | Thrombin and coagulation factor VII | serum prothrombin conversion accelerator |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 51599.89 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 466 |
|---|
| Sequence: | MVSQALRLLCLLLGLQGCLAAGGVAKASGGETRDMPWKPGPHRVFVTQEEAHGVLHRRRR
ANAFLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGS
CKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSL
LADGVSCTPTVEYPCGKIPILEKRNASKPQGRIVGGKVCPKGECPWQVLLLVNGAQLCGG
TLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTN
HDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVL
NVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTG
IVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLRAPFP
|
|
|
|---|
| BDBM13564 |
|---|
| BDBM13553 |
|---|
| Name | BDBM13564 |
|---|
| Synonyms: | 2-[(4-carbamimidoylphenyl)amino]-2-{3-ethoxy-5-[(1-methanesulfonylpiperidin-4-yl)oxy]phenyl}acetic acid | phenylglycine deriv. 12 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H30N4O6S |
|---|
| Mol. Mass. | 490.573 |
|---|
| SMILES | CCOc1cc(OC2CCN(CC2)S(C)(=O)=O)cc(c1)C(Nc1ccc(cc1)C(N)=N)C(O)=O |
|---|
| Structure | 
|
|---|
Search and Browse
