Reaction Details |
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Target | Tyrosine-protein phosphatase non-receptor type 1 |
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Ligand | BDBM13611 |
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Substrate/Competitor | BDBM13466 |
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Meas. Tech. | PTP1B Inhibition Assay |
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pH | 7.2±n/a |
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Temperature | 295.15±n/a K |
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Ki | 250±n/a nM |
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Citation | Bleasdale, JE; Ogg, D; Palazuk, BJ; Jacob, CS; Swanson, ML; Wang, XY; Thompson, DP; Conradi, RA; Mathews, WR; Laborde, AL; Stuchly, CW; Heijbel, A; Bergdahl, K; Bannow, CA; Smith, CW; Svensson, C; Liljebris, C; Schostarez, HJ; May, PD; Stevens, FC; Larsen, SD Small molecule peptidomimetics containing a novel phosphotyrosine bioisostere inhibit protein tyrosine phosphatase 1B and augment insulin action. Biochemistry40:5642-54 (2001) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Tyrosine-protein phosphatase non-receptor type 1 |
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Name: | Tyrosine-protein phosphatase non-receptor type 1 |
Synonyms: | PTN1_RAT | PTP-1B | PTPase 1B | Protein-Tyrosine Phosphatase 1B (PTP1B) | Ptpn1 | Tyrosine-protein phosphatase, non-receptor type 1 |
Type: | Enzyme |
Mol. Mass.: | 49669.91 |
Organism: | Rattus norvegicus (rat) |
Description: | n/a |
Residue: | 432 |
Sequence: | MEMEKEFEQIDKAGNWAAIYQDIRHEASDFPCRIAKLPKNKNRNRYRDVSPFDHSRIKLH
QEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRIMEKGSLK
CAQYWPQKEEKEMVFDDTNLKLTLISEDVKSYYTVRQLELENLATQEAREILHFHYTTWP
DFGVPESPASFLNFLFKVRESGSLSPEHGPIVVHCSAGIGRSGTFCLADTCLLLMDKRKD
PSSVDIKKVLLEMRRFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLE
PPPEHVPPPPRPPKRTLEPHNGKCKELFSNHQWVSEESCEDEDILAREESRAPSIAVHSM
SSMSQDTEVRKRMVGGGLQSAQASVPTEEELSPTEEEQKAHRPVHWKPFLVNVCMATALA
TGAYLCYRVCFH
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BDBM13611 |
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BDBM13466 |
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Name | BDBM13611 |
Synonyms: | 2-(carboxymethoxy)-5-[(2S)-2-[(2S)-2-(3-formamidopropanoic acid)-3-phenylpropanamido]-2-(pentylcarbamoyl)ethyl]benzoic acid | CHEMBL175198 | Compound VI | sulfotyrosyl tripeptide analog 6 |
Type | Small organic molecule |
Emp. Form. | C30H37N3O10 |
Mol. Mass. | 599.6289 |
SMILES | CCCCCNC(=O)[C@H](Cc1ccc(OCC(O)=O)c(c1)C(O)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCC(O)=O |r| |
Structure |
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