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TargetTyrosine-protein phosphatase non-receptor type 1
LigandBDBM13611
Substrate/CompetitorBDBM13466
Meas. Tech.PTP1B Inhibition Assay
pH7.2±n/a
Temperature295.15±n/a K
Ki 250±n/a nM
Citation Bleasdale, JEOgg, DPalazuk, BJJacob, CSSwanson, MLWang, XYThompson, DPConradi, RAMathews, WRLaborde, ALStuchly, CWHeijbel, ABergdahl, KBannow, CASmith, CWSvensson, CLiljebris, CSchostarez, HJMay, PDStevens, FCLarsen, SD Small molecule peptidomimetics containing a novel phosphotyrosine bioisostere inhibit protein tyrosine phosphatase 1B and augment insulin action. Biochemistry40:5642-54 (2001) [PubMed]  Article
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Tyrosine-protein phosphatase non-receptor type 1
Name:Tyrosine-protein phosphatase non-receptor type 1
Synonyms:PTN1_RAT | PTP-1B | PTPase 1B | Protein-Tyrosine Phosphatase 1B (PTP1B) | Ptpn1 | Tyrosine-protein phosphatase, non-receptor type 1
Type:Enzyme
Mol. Mass.:49669.91
Organism:Rattus norvegicus (rat)
Description:n/a
Residue:432
Sequence:
MEMEKEFEQIDKAGNWAAIYQDIRHEASDFPCRIAKLPKNKNRNRYRDVSPFDHSRIKLH
QEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRIMEKGSLK
CAQYWPQKEEKEMVFDDTNLKLTLISEDVKSYYTVRQLELENLATQEAREILHFHYTTWP
DFGVPESPASFLNFLFKVRESGSLSPEHGPIVVHCSAGIGRSGTFCLADTCLLLMDKRKD
PSSVDIKKVLLEMRRFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLE
PPPEHVPPPPRPPKRTLEPHNGKCKELFSNHQWVSEESCEDEDILAREESRAPSIAVHSM
SSMSQDTEVRKRMVGGGLQSAQASVPTEEELSPTEEEQKAHRPVHWKPFLVNVCMATALA
TGAYLCYRVCFH
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  Blast E-value cutoff:
BDBM13611
BDBM13466
NameBDBM13611
Synonyms:2-(carboxymethoxy)-5-[(2S)-2-[(2S)-2-(3-formamidopropanoic acid)-3-phenylpropanamido]-2-(pentylcarbamoyl)ethyl]benzoic acid | CHEMBL175198 | Compound VI | sulfotyrosyl tripeptide analog 6
TypeSmall organic molecule
Emp. Form.C30H37N3O10
Mol. Mass.599.6289
SMILESCCCCCNC(=O)[C@H](Cc1ccc(OCC(O)=O)c(c1)C(O)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCC(O)=O |r|
Structure
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