Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetDipeptidyl peptidase 1
LigandBDBM201027
Substrate/Competitorn/a
Meas. Tech.Inhibition of Human DPPI (Cathepsin C)
Temperature298.15±n/a K
IC50 0.500±0 nM
Commentsextracted
Citation Vintonyak, VGrauert, MGrundl, MPautsch, A Substituted spirocycles US Patent US9540373 Publication Date 1/10/2017
More Info.:Get all data from this article,  Assay Method
 
Dipeptidyl peptidase 1
Name:Dipeptidyl peptidase 1
Synonyms:CATC_HUMAN | CPPI | CTSC | Cathepsin C | Cathepsin J | Dipeptidyl peptidase 1 (DDPI) | Dipeptidyl peptidase 1 (DPPI) | Dipeptidyl peptidase I | Dipeptidyl peptidase I (DPPI)
Type:Enzyme
Mol. Mass.:51857.28
Organism:Homo sapiens (Human)
Description:P53634
Residue:463
Sequence:
MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQ
EKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNE
TMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINA
IQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNV
HGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEG
GFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALM
KLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGM
DYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM201027
n/a
NameBDBM201027
Synonyms:US9540373, 16 | US9879026, Example 16 | USRE47636, Example 16
TypeSmall organic molecule
Emp. Form.C27H28FN5O2
Mol. Mass.473.5419
SMILESFc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc2NC(=O)C3(CCNC3)c2c1 |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: