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TargetFlap endonuclease 1
LigandBDBM283677
Substrate/Competitorn/a
Meas. Tech.Binding Assay
Ki<1±n/a nM
CommentsZero 01/04/2022
Citation Bacani, GMEccles, WFitzgerald, AEGoldberg, SDHack, MDHawryluk, NAJones, WMKeith, JMKrawczuk, PLebsack, ADLee-Dutra, ALiu, JMcClure, KJMeduna, SPPippel, DJRosen, MDSales, ZS Flap modulators US Patent US9745328 Publication Date 8/29/2017
More Info.:Get all data from this article,  Assay Method
 
Flap endonuclease 1
Name:Flap endonuclease 1
Synonyms:DNase IV | FEN-1 | FEN1 | FEN1_HUMAN | Flap structure-specific endonuclease 1 | MF1 | Maturation factor 1 | RAD2 | hFEN-1
Type:PROTEIN
Mol. Mass.:42602.57
Organism:Homo sapiens (Human)
Description:ChEMBL_1517026
Residue:380
Sequence:
MGIQGLAKLIADVAPSAIRENDIKSYFGRKVAIDASMSIYQFLIAVRQGGDVLQNEEGET
TSHLMGMFYRTIRMMENGIKPVYVFDGKPPQLKSGELAKRSERRAEAEKQLQQAQAAGAE
QEVEKFTKRLVKVTKQHNDECKHLLSLMGIPYLDAPSEAEASCAALVKAGKVYAAATEDM
DCLTFGSPVLMRHLTASEAKKLPIQEFHLSRILQELGLNQEQFVDLCILLGSDYCESIRG
IGPKRAVDLIQKHKSIEEIVRRLDPNKYPVPENWLHKEAHQLFLEPEVLDPESVELKWSE
PNEEELIKFMCGEKQFSEERIRSGVKRLSKSRQGSTQGRLDDFFKVTGSLSSAKRKEPEP
KGSTKKKAKTGAAGKFKRGK
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  Blast E-value cutoff:
BDBM283677
n/a
NameBDBM283677
Synonyms:5-[3-Fluoro-2'-(pyrimidin-2-yloxy)-4'- (trifluoromethyl)biphenyl-4-yl]pyrazin-2-amine | US9745328, Compound 551 | US9884878, Compound 551
TypeSmall organic molecule
Emp. Form.C21H13F4N5O
Mol. Mass.427.3544
SMILESNc1cnc(cn1)-c1ccc(cc1F)-c1ccc(cc1Oc1ncccn1)C(F)(F)F
Structure
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