| Reaction Details |
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 | Report a problem with these data |
| Target | Flap endonuclease 1 |
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| Ligand | BDBM169270 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Binding Assay |
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| Ki | 0.700±n/a nM |
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| Citation |  Bacani, GM; Eccles, W; Fitzgerald, AE; Goldberg, SD; Hack, MD; Hawryluk, NA; Jones, WM; Keith, JM; Krawczuk, P; Lebsack, AD; Lee-Dutra, A; Liu, J; McClure, KJ; Meduna, SP; Pippel, DJ; Rosen, MD; Sales, ZS Flap modulators US Patent US9745328 Publication Date 8/29/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Flap endonuclease 1 |
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| Name: | Flap endonuclease 1 |
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| Synonyms: | DNase IV | FEN-1 | FEN1 | FEN1_HUMAN | Flap structure-specific endonuclease 1 | MF1 | Maturation factor 1 | RAD2 | hFEN-1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 42602.57 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1517026 |
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| Residue: | 380 |
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| Sequence: | MGIQGLAKLIADVAPSAIRENDIKSYFGRKVAIDASMSIYQFLIAVRQGGDVLQNEEGET
TSHLMGMFYRTIRMMENGIKPVYVFDGKPPQLKSGELAKRSERRAEAEKQLQQAQAAGAE
QEVEKFTKRLVKVTKQHNDECKHLLSLMGIPYLDAPSEAEASCAALVKAGKVYAAATEDM
DCLTFGSPVLMRHLTASEAKKLPIQEFHLSRILQELGLNQEQFVDLCILLGSDYCESIRG
IGPKRAVDLIQKHKSIEEIVRRLDPNKYPVPENWLHKEAHQLFLEPEVLDPESVELKWSE
PNEEELIKFMCGEKQFSEERIRSGVKRLSKSRQGSTQGRLDDFFKVTGSLSSAKRKEPEP
KGSTKKKAKTGAAGKFKRGK
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| BDBM169270 |
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| n/a |
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| Name | BDBM169270 |
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| Synonyms: | US9079866, 675 | US9745328, Compound 675 | US9884878, Compound 675 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H20FN5O2S |
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| Mol. Mass. | 401.458 |
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| SMILES | CC(C)(C)NS(=O)(=O)c1ccccc1-c1cnc(c(F)c1)-c1cnc(N)nc1 |
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| Structure | 
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