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TargetFlap endonuclease 1
LigandBDBM169270
Substrate/Competitorn/a
Meas. Tech.Binding Assay
Ki 0.700±n/a nM
Citation Bacani GMEccles WFitzgerald AEGoldberg SDHack MDHawryluk NAJones WMKeith JMKrawczuk PLebsack ADLee-Dutra ALiu JMcClure KJMeduna SPPippel DJRosen MDSales ZS Flap modulators US Patent  US9745328 Publication Date 8/29/2017
More Info.:Get all data from this article,  Assay Method
 
Flap endonuclease 1
Name:Flap endonuclease 1
Synonyms:DNase IV | FEN-1 | FEN1 | Flap structure-specific endonuclease 1 | MF1 | Maturation factor 1 | RAD2 | hFEN-1
Type:PROTEIN
Mol. Mass.:42602.57
Organism:Homo sapiens (Human)
Description:ChEMBL_1517026
Residue:380
Sequence:
MGIQGLAKLIADVAPSAIRENDIKSYFGRKVAIDASMSIYQFLIAVRQGGDVLQNEEGET
TSHLMGMFYRTIRMMENGIKPVYVFDGKPPQLKSGELAKRSERRAEAEKQLQQAQAAGAE
QEVEKFTKRLVKVTKQHNDECKHLLSLMGIPYLDAPSEAEASCAALVKAGKVYAAATEDM
DCLTFGSPVLMRHLTASEAKKLPIQEFHLSRILQELGLNQEQFVDLCILLGSDYCESIRG
IGPKRAVDLIQKHKSIEEIVRRLDPNKYPVPENWLHKEAHQLFLEPEVLDPESVELKWSE
PNEEELIKFMCGEKQFSEERIRSGVKRLSKSRQGSTQGRLDDFFKVTGSLSSAKRKEPEP
KGSTKKKAKTGAAGKFKRGK
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM169270
n/a
NameBDBM169270
Synonyms:US9079866, 675 | US9745328, Compound 675 | US9884878, Compound 675
TypeSmall organic molecule
Emp. Form.C19H20FN5O2S
Mol. Mass.401.458
SMILESCC(C)(C)NS(=O)(=O)c1ccccc1-c1cnc(c(F)c1)-c1cnc(N)nc1
Structure
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