Reaction Details |
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Target | Nuclear receptor ROR-gamma |
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Ligand | BDBM338462 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Binding Assay |
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IC50 | 2.00±n/a nM |
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Citation | Fauber, B; Gobbi, A; Rene, O; van Niel, MB; Gancia, E; Gaines, S; Ladduwahetty, T; Vesey, D; Ward, S; Winship, P Aryl sultam derivatives as RORc modulators US Patent US9751873 Publication Date 9/5/2017 |
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More Info.: | Get all data from this article, Assay Method |
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Nuclear receptor ROR-gamma |
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Name: | Nuclear receptor ROR-gamma |
Synonyms: | NR1F3 | Nuclear receptor ROR-gamma | Nuclear receptor ROR-gamma (RORC) | Nuclear receptor subfamily 1 group F member 3 | RAR-related orphan receptor C (RORc) | RORC | RORG | RORG_HUMAN | RZRG | Retinoid-related orphan receptor-gamma | Retinoid-related orphan receptor-gamma (RORc) |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 58218.40 |
Organism: | Homo sapiens (Human) |
Description: | P51449 |
Residue: | 518 |
Sequence: | MDRAPQRQHRASRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQR
CNAAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQK
QLQQRQQQQQEPVVKTPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKAS
GSGPSYSNNLAKAGLNGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPG
LGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIF
SREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEV
VLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALY
TALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHV
ERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK
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BDBM338462 |
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n/a |
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Name | BDBM338462 |
Synonyms: | (3S,6R)-3-ethyl-2-[[2-fluoro-4- [(1R,5S)-6-(1,2,4-triazol-4-yl)-3- azabicyclo[3.1.0]hexan-3- yl]phenyl]methyl]-6-phenyl- thiazinane 1,1-dioxide | US9751873, Example 149 |
Type | Small organic molecule |
Emp. Form. | C26H30FN5O2S |
Mol. Mass. | 495.612 |
SMILES | CC[C@H]1CC[C@H](c2ccccc2)S(=O)(=O)N1Cc1ccc(cc1F)N1C[C@H]2[C@@H](C1)[C@@H]2n1cnnc1 |r| |
Structure |
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