Reaction Details |
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Target | Dimer of Gag-Pol polyprotein [489-587,K509R,V521I,L522F,M525I,L552P,A560V,V571A,I573V,L579M] |
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Ligand | BDBM520 |
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Substrate/Competitor | HIV Protease Chromogenic Peptide Substrate |
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Meas. Tech. | Protease Inhibition Assay |
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Ki | 165±n/a nM |
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Citation | Clemente, JC; Moose, RE; Hemrajani, R; Whitford, LR; Govindasamy, L; Reutzel, R; McKenna, R; Agbandje-McKenna, M; Goodenow, MM; Dunn, BM Comparing the accumulation of active- and nonactive-site mutations in the HIV-1 protease. Biochemistry43:12141-51 (2004) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Dimer of Gag-Pol polyprotein [489-587,K509R,V521I,L522F,M525I,L552P,A560V,V571A,I573V,L579M] |
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Name: | Dimer of Gag-Pol polyprotein [489-587,K509R,V521I,L522F,M525I,L552P,A560V,V571A,I573V,L579M] |
Synonyms: | HIV-1 Protease Mutant V6(84) | HIV-1 protease mutant (K20R V32I L33F M36I L63P A71V V82A I84V L90M) |
Type: | Protein Complex |
Mol. Mass.: | n/a |
Description: | The post-ritonavir therapy protease variant plus I84V mutation, which was created by site-directed mutagenesis. |
Components: | This complex has 2 components. |
Component 1 |
Name: | Gag-Pol polyprotein [489-587,K509R,V521I,L522F,M525I,L552P,A560V,V571A,I573V,L579M] |
Synonyms: | HIV-1 Protease Mutant V6(84) chain A | HIV-1 Protease Mutant V6(84) chain B | POL_HV1H2 | gag-pol |
Type: | Enzyme Subunit |
Mol. Mass.: | 10827.15 |
Organism: | Human immunodeficiency virus type 1 |
Description: | P04585[489-587,K509R,V521I,L522F,M525I,L552P,A560V,V571A,I573V,L579M] |
Residue: | 99 |
Sequence: | PQVTLWQRPLVTIKIGGQLREALLDTGADDTIFEEISLPGRWKPKMIGGIGGFIKVRQYD
QIPIEICGHKVIGTVLVGPTPANVIGRNLMTQIGCTLNF
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Component 2 |
Name: | Gag-Pol polyprotein [489-587,K509R,V521I,L522F,M525I,L552P,A560V,V571A,I573V,L579M] |
Synonyms: | HIV-1 Protease Mutant V6(84) chain A | HIV-1 Protease Mutant V6(84) chain B | POL_HV1H2 | gag-pol |
Type: | Enzyme Subunit |
Mol. Mass.: | 10827.15 |
Organism: | Human immunodeficiency virus type 1 |
Description: | P04585[489-587,K509R,V521I,L522F,M525I,L552P,A560V,V571A,I573V,L579M] |
Residue: | 99 |
Sequence: | PQVTLWQRPLVTIKIGGQLREALLDTGADDTIFEEISLPGRWKPKMIGGIGGFIKVRQYD
QIPIEICGHKVIGTVLVGPTPANVIGRNLMTQIGCTLNF
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BDBM520 |
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HIV Protease Chromogenic Peptide Substrate |
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Name: | HIV Protease Chromogenic Peptide Substrate |
Synonyms: | n/a |
Type: | Peptide |
Mol. Mass.: | 1420.11 |
Organism: | n/a |
Description: | n/a |
Residue: | 13 |
Sequence: | |