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TargetFibroblast growth factor receptor 4
LigandBDBM339811
Substrate/Competitorn/a
Meas. Tech.FGFR4 (Enzymatic Assay)
IC50 1.15±n/a nM
Citation Angibaud PRObringer MMarin JJJeanty M Naphthyridine derivative compounds US Patent  US9757364 Publication Date 9/12/2017
More Info.:Get all data from this article,  Assay Method
 
Fibroblast growth factor receptor 4
Name:Fibroblast growth factor receptor 4
Synonyms:CD_antigen: CD334 FGFR4 | FGFR-4 | Fibroblast growth factor receptor 4 (FGFR4) | JK2 | TKF
Type:Protein
Mol. Mass.:87957.45
Organism:Homo sapiens (Human)
Description:P22455
Residue:802
Sequence:
MRLLLALLGVLLSVPGPPVLSLEASEEVELEPCLAPSLEQQEQELTVALGQPVRLCCGRA
ERGGHWYKEGSRLAPAGRVRGWRGRLEIASFLPEDAGRYLCLARGSMIVLQNLTLITGDS
LTSSNDDEDPKSHRDPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTP
TIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLD
VLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFP
YVQVLKTADINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPEEDPTWTA
AAPEARYTDIILYASGSLALAVLLLLAGLYRGQALHGRHPRPPATVQKLSRFPLARQFSL
ESGSSGKSSSSLVRGVRLSSSGPALLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQ
VVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVC
TQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGM
QYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEA
LFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYG
LMRECWHAAPSQRPTFKQLVEALDKVLLAVSEEYLDLRLTFGPYSPSGGDASSTCSSSDS
VFSHDPLPLGSSSFPFGSGVQT
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM339811
n/a
NameBDBM339811
Synonyms:US9757364, Compound 65
TypeSmall organic molecule
Emp. Form.C24H21F2N7O2
Mol. Mass.477.466
SMILESCOc1cc(OC)c(F)c(N(Cc2ncc[nH]2)c2ccc3ncc(cc3n2)-c2cnn(C)c2)c1F
Structure
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