Reaction Details |
| Report a problem with these data |
Target | Tyrosine-protein phosphatase non-receptor type 1 [1-298] |
---|
Ligand | BDBM14239 |
---|
Substrate/Competitor | BDBM13466 |
---|
Meas. Tech. | Enzymatic Assay |
---|
Temperature | 298.15±n/a K |
---|
Ki | 370±n/a nM |
---|
Comments | extracted |
---|
Citation | Moretto, AF; Kirincich, SJ; Xu, WX; Smith, MJ; Wan, ZK; Wilson, DP; Follows, BC; Binnun, E; Joseph-McCarthy, D; Foreman, K; Erbe, DV; Zhang, YL; Tam, SK; Tam, SY; Lee, J Bicyclic and tricyclic thiophenes as protein tyrosine phosphatase 1B inhibitors. Bioorg Med Chem14:2162-77 (2006) [PubMed] Article |
---|
More Info.: | Get all data from this article, Solution Info, Assay Method |
---|
|
Tyrosine-protein phosphatase non-receptor type 1 [1-298] |
---|
Name: | Tyrosine-protein phosphatase non-receptor type 1 [1-298] |
Synonyms: | PTN1_HUMAN | PTP-1B | PTP1B | PTPN1 | PTPase 1B | Protein-Tyrosine Phosphatase 1B (PTP1B) | Tyrosine-protein phosphatase, non-receptor type 1 |
Type: | Enzyme |
Mol. Mass.: | 34670.65 |
Organism: | Homo sapiens (Human) |
Description: | The catalytic domain of PTP 1B (residues 1-298) was expressed and purified from E. coli. |
Residue: | 298 |
Sequence: | MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLH
QEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLK
CAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWP
DFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKD
PSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHED
|
|
|
BDBM14239 |
---|
BDBM13466 |
---|
Name | BDBM14239 |
Synonyms: | 5-(carboxymethoxy)-10-{[1-(phenylmethane)sulfonylpiperidin-4-yl]amino}-3,7-dithiatricyclo[6.4.0.0^{2,6}]dodeca-1(8),2(6),4,9,11-pentaene-4-carboxylic acid | thienobenzothiophene 29 |
Type | Small organic molecule |
Emp. Form. | C25H24N2O7S3 |
Mol. Mass. | 560.662 |
SMILES | OC(=O)COc1c(sc2c1sc1cc(NC3CCN(CC3)S(=O)(=O)Cc3ccccc3)ccc21)C(O)=O |
Structure |
|