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TargetTyrosine-protein phosphatase non-receptor type 1 [1-298]
LigandBDBM14239
Substrate/CompetitorBDBM13466
Meas. Tech.Enzymatic Assay
Temperature298.15±n/a K
Ki 370±n/a nM
Commentsextracted
Citation Moretto, AFKirincich, SJXu, WXSmith, MJWan, ZKWilson, DPFollows, BCBinnun, EJoseph-McCarthy, DForeman, KErbe, DVZhang, YLTam, SKTam, SYLee, J Bicyclic and tricyclic thiophenes as protein tyrosine phosphatase 1B inhibitors. Bioorg Med Chem14:2162-77 (2006) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Tyrosine-protein phosphatase non-receptor type 1 [1-298]
Name:Tyrosine-protein phosphatase non-receptor type 1 [1-298]
Synonyms:PTN1_HUMAN | PTP-1B | PTP1B | PTPN1 | PTPase 1B | Protein-Tyrosine Phosphatase 1B (PTP1B) | Tyrosine-protein phosphatase, non-receptor type 1
Type:Enzyme
Mol. Mass.:34670.65
Organism:Homo sapiens (Human)
Description:The catalytic domain of PTP 1B (residues 1-298) was expressed and purified from E. coli.
Residue:298
Sequence:
MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLH
QEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLK
CAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWP
DFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKD
PSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHED
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BDBM14239
BDBM13466
NameBDBM14239
Synonyms:5-(carboxymethoxy)-10-{[1-(phenylmethane)sulfonylpiperidin-4-yl]amino}-3,7-dithiatricyclo[6.4.0.0^{2,6}]dodeca-1(8),2(6),4,9,11-pentaene-4-carboxylic acid | thienobenzothiophene 29
TypeSmall organic molecule
Emp. Form.C25H24N2O7S3
Mol. Mass.560.662
SMILESOC(=O)COc1c(sc2c1sc1cc(NC3CCN(CC3)S(=O)(=O)Cc3ccccc3)ccc21)C(O)=O
Structure
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