| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Mitotic checkpoint serine/threonine-protein kinase BUB1 |
|---|
| Ligand | BDBM341156 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Time-Resolved Fluorescence Energy Transfer (TR-FRET) Kinase Assay |
|---|
| IC50 | 24.0±n/a nM |
|---|
| Citation |  Hitchcock, M; Mengel, A; Richter, A; Briem, H; Siemeister, G; Bone, W; Fernandez-Montalvan, AE; Schröder, J; Holton, S; Preuβe, C; Mönning, U Substituted benzylpyrazoles US Patent US9765058 Publication Date 9/19/2017 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Mitotic checkpoint serine/threonine-protein kinase BUB1 |
|---|
| Name: | Mitotic checkpoint serine/threonine-protein kinase BUB1 |
|---|
| Synonyms: | BUB1 | BUB1A | BUB1L | BUB1_HUMAN | hBUB1 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 122372.31 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1510603 |
|---|
| Residue: | 1085 |
|---|
| Sequence: | MDTPENVLQMLEAHMQSYKGNDPLGEWERYIQWVEENFPENKEYLITLLEHLMKEFLDKK
KYHNDPRFISYCLKFAEYNSDLHQFFEFLYNHGIGTLSSPLYIAWAGHLEAQGELQHASA
VLQRGIQNQAEPREFLQQQYRLFQTRLTETHLPAQARTSEPLHNVQVLNQMITSKSNPGN
NMACISKNQGSELSGVISSACDKESNMERRVITISKSEYSVHSSLASKVDVEQVVMYCKE
KLIRGESEFSFEELRAQKYNQRRKHEQWVNEDRHYMKRKEANAFEEQLLKQKMDELHKKL
HQVVETSHEDLPASQERSEVNPARMGPSVGSQQELRAPCLPVTYQQTPVNMEKNPREAPP
VVPPLANAISAALVSPATSQSIAPPVPLKAQTVTDSMFAVASKDAGCVNKSTHEFKPQSG
AEIKEGCETHKVANTSSFHTTPNTSLGMVQATPSKVQPSPTVHTKEALGFIMNMFQAPTL
PDISDDKDEWQSLDQNEDAFEAQFQKNVRSSGAWGVNKIISSLSSAFHVFEDGNKENYGL
PQPKNKPTGARTFGERSVSRLPSKPKEEVPHAEEFLDDSTVWGIRCNKTLAPSPKSPGDF
TSAAQLASTPFHKLPVESVHILEDKENVVAKQCTQATLDSCEENMVVPSRDGKFSPIQEK
SPKQALSSHMYSASLLRLSQPAAGGVLTCEAELGVEACRLTDTDAAIAEDPPDAIAGLQA
EWMQMSSLGTVDAPNFIVGNPWDDKLIFKLLSGLSKPVSSYPNTFEWQCKLPAIKPKTEF
QLGSKLVYVHHLLGEGAFAQVYEATQGDLNDAKNKQKFVLKVQKPANPWEFYIGTQLMER
LKPSMQHMFMKFYSAHLFQNGSVLVGELYSYGTLLNAINLYKNTPEKVMPQGLVISFAMR
MLYMIEQVHDCEIIHGDIKPDNFILGNGFLEQDDEDDLSAGLALIDLGQSIDMKLFPKGT
IFTAKCETSGFQCVEMLSNKPWNYQIDYFGVAATVYCMLFGTYMKVKNEGGECKPEGLFR
RLPHLDMWNEFFHVMLNIPDCHHLPSLDLLRQKLKKVFQQHYTNKIRALRNRLIVLLLEC
KRSRK
|
|
|
|---|
| BDBM341156 |
|---|
| n/a |
|---|
| Name | BDBM341156 |
|---|
| Synonyms: | US9765058, Example 2-2-4 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H21BrF2N6O2 |
|---|
| Mol. Mass. | 531.353 |
|---|
| SMILES | CCOc1cc(F)c(Cn2nc(c(Br)c2C)-c2ncc(OC)c(Nc3ccncc3)n2)c(F)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
