| Reaction Details |
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 | Report a problem with these data |
| Target | Mitotic checkpoint serine/threonine-protein kinase BUB1 |
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| Ligand | BDBM341164 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Time-Resolved Fluorescence Energy Transfer (TR-FRET) Kinase Assay |
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| IC50 | 11.0±n/a nM |
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| Citation |  Hitchcock, M; Mengel, A; Richter, A; Briem, H; Siemeister, G; Bone, W; Fernandez-Montalvan, AE; Schröder, J; Holton, S; Preuβe, C; Mönning, U Substituted benzylpyrazoles US Patent US9765058 Publication Date 9/19/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Mitotic checkpoint serine/threonine-protein kinase BUB1 |
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| Name: | Mitotic checkpoint serine/threonine-protein kinase BUB1 |
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| Synonyms: | BUB1 | BUB1A | BUB1L | BUB1_HUMAN | hBUB1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 122372.31 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1510603 |
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| Residue: | 1085 |
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| Sequence: | MDTPENVLQMLEAHMQSYKGNDPLGEWERYIQWVEENFPENKEYLITLLEHLMKEFLDKK
KYHNDPRFISYCLKFAEYNSDLHQFFEFLYNHGIGTLSSPLYIAWAGHLEAQGELQHASA
VLQRGIQNQAEPREFLQQQYRLFQTRLTETHLPAQARTSEPLHNVQVLNQMITSKSNPGN
NMACISKNQGSELSGVISSACDKESNMERRVITISKSEYSVHSSLASKVDVEQVVMYCKE
KLIRGESEFSFEELRAQKYNQRRKHEQWVNEDRHYMKRKEANAFEEQLLKQKMDELHKKL
HQVVETSHEDLPASQERSEVNPARMGPSVGSQQELRAPCLPVTYQQTPVNMEKNPREAPP
VVPPLANAISAALVSPATSQSIAPPVPLKAQTVTDSMFAVASKDAGCVNKSTHEFKPQSG
AEIKEGCETHKVANTSSFHTTPNTSLGMVQATPSKVQPSPTVHTKEALGFIMNMFQAPTL
PDISDDKDEWQSLDQNEDAFEAQFQKNVRSSGAWGVNKIISSLSSAFHVFEDGNKENYGL
PQPKNKPTGARTFGERSVSRLPSKPKEEVPHAEEFLDDSTVWGIRCNKTLAPSPKSPGDF
TSAAQLASTPFHKLPVESVHILEDKENVVAKQCTQATLDSCEENMVVPSRDGKFSPIQEK
SPKQALSSHMYSASLLRLSQPAAGGVLTCEAELGVEACRLTDTDAAIAEDPPDAIAGLQA
EWMQMSSLGTVDAPNFIVGNPWDDKLIFKLLSGLSKPVSSYPNTFEWQCKLPAIKPKTEF
QLGSKLVYVHHLLGEGAFAQVYEATQGDLNDAKNKQKFVLKVQKPANPWEFYIGTQLMER
LKPSMQHMFMKFYSAHLFQNGSVLVGELYSYGTLLNAINLYKNTPEKVMPQGLVISFAMR
MLYMIEQVHDCEIIHGDIKPDNFILGNGFLEQDDEDDLSAGLALIDLGQSIDMKLFPKGT
IFTAKCETSGFQCVEMLSNKPWNYQIDYFGVAATVYCMLFGTYMKVKNEGGECKPEGLFR
RLPHLDMWNEFFHVMLNIPDCHHLPSLDLLRQKLKKVFQQHYTNKIRALRNRLIVLLLEC
KRSRK
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| BDBM341164 |
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| n/a |
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| Name | BDBM341164 |
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| Synonyms: | Preparation of 4-({2-[4-chloro-5-cyclopropyl-1-(4-ethoxy-2,6-difluorobenzyl)-1H-pyrazol-3-yl]pyrimidin-4-yl}amino)nicotinic acid | US9765058, Example 2-3-1 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H21ClF2N6O3 |
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| Mol. Mass. | 526.922 |
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| SMILES | CCOc1cc(F)c(Cn2nc(c(Cl)c2C2CC2)-c2nccc(Nc3ccncc3C(O)=O)n2)c(F)c1 |
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| Structure | 
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